2X8J
Intracellular subtilisin precursor from B. clausii
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 1317 |
| Chain | Residue |
| C | ASP58 |
| C | ALA97 |
| C | THR99 |
| C | SER101 |
| C | VAL103 |
| C | HOH2107 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1317 |
| Chain | Residue |
| A | SER101 |
| A | VAL103 |
| A | HOH2099 |
| A | ASP58 |
| A | ALA97 |
| A | THR99 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1PE A 1318 |
| Chain | Residue |
| A | ALA198 |
| A | TYR200 |
| A | ASN201 |
| A | GLU202 |
| A | VAL203 |
| A | ALA205 |
| A | GLU224 |
| A | ASP226 |
| A | GLU277 |
| A | TYR281 |
| A | HOH2171 |
| A | HOH2241 |
| B | GLU279 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1317 |
| Chain | Residue |
| B | ASP58 |
| B | ALA97 |
| B | THR99 |
| B | SER101 |
| B | VAL103 |
| B | HOH2080 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1PE B 1318 |
| Chain | Residue |
| A | GLU279 |
| B | ALA198 |
| B | TYR200 |
| B | ASN201 |
| B | GLU202 |
| B | VAL203 |
| B | GLU224 |
| B | ASP226 |
| B | GLU277 |
| B | TYR281 |
| B | HOH2125 |
| B | HOH2208 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1PE C 1319 |
| Chain | Residue |
| C | ALA198 |
| C | TYR200 |
| C | ASN201 |
| C | GLU202 |
| C | VAL203 |
| C | ALA205 |
| C | GLU224 |
| C | ASP226 |
| C | GLU277 |
| C | TYR281 |
| C | HOH2199 |
| C | HOH2261 |
| D | GLU279 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 1320 |
| Chain | Residue |
| C | ASN201 |
| C | HOH2262 |
| C | HOH2263 |
| C | HOH2264 |
| D | ASN174 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 1317 |
| Chain | Residue |
| D | ASP58 |
| D | ALA97 |
| D | THR99 |
| D | SER101 |
| D | VAL103 |
| D | HOH2073 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 1PE D 1318 |
| Chain | Residue |
| C | ARG273 |
| C | GLU279 |
| D | ALA198 |
| D | TYR200 |
| D | ASN201 |
| D | GLU202 |
| D | VAL203 |
| D | ALA205 |
| D | GLU224 |
| D | ASP226 |
| D | GLU277 |
| D | TYR281 |
| D | HOH2150 |
| D | HOH2212 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 1319 |
| Chain | Residue |
| C | ASN300 |
| D | ALA267 |
| D | ALA270 |
| D | GLN283 |
| D | ARG286 |
| D | ARG287 |
| D | HOH2213 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA E 1317 |
| Chain | Residue |
| E | ASP58 |
| E | ALA97 |
| E | THR99 |
| E | SER101 |
| E | VAL103 |
| E | HOH2098 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1PE E 1318 |
| Chain | Residue |
| E | ALA205 |
| E | GLU224 |
| E | ASP226 |
| E | GLU277 |
| E | TYR281 |
| E | HOH2197 |
| E | HOH2265 |
| F | GLU279 |
| E | ALA198 |
| E | TYR200 |
| E | ASN201 |
| E | GLU202 |
| E | VAL203 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA F 1317 |
| Chain | Residue |
| F | ASP58 |
| F | ALA97 |
| F | THR99 |
| F | SER101 |
| F | VAL103 |
| F | HOH2119 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1PE F 1318 |
| Chain | Residue |
| E | GLU279 |
| F | ALA198 |
| F | TYR200 |
| F | ASN201 |
| F | GLU202 |
| F | VAL203 |
| F | ALA205 |
| F | GLU224 |
| F | ASP226 |
| F | GLU277 |
| F | TYR281 |
| F | HOH2235 |
| F | HOH2310 |
Functional Information from PROSITE/UniProt
| site_id | PS00136 |
| Number of Residues | 12 |
| Details | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. IGVIDTGCqvdH |
| Chain | Residue | Details |
| B | ILE45-HIS56 | |
| A | ILE45-HIS56 |
| site_id | PS00137 |
| Number of Residues | 11 |
| Details | SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA |
| Chain | Residue | Details |
| B | HIS86-ALA96 | |
| A | HIS86-ALA96 |
