Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1471 |
| Chain | Residue |
| A | TRP93 |
| A | ARG125 |
| A | MET151 |
| A | GLU152 |
| A | HOH2278 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1472 |
| Chain | Residue |
| A | HOH2105 |
| A | HOH2144 |
| A | HOH2194 |
| A | HIS318 |
| A | HOH2009 |
| A | HOH2012 |
| A | HOH2104 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1473 |
| Chain | Residue |
| A | ASN406 |
| A | LYS407 |
| A | ASN408 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1474 |
| Chain | Residue |
| A | ASP103 |
| A | VAL104 |
| A | THR105 |
| A | HOH2015 |
| A | HOH2016 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1475 |
| Chain | Residue |
| A | VAL73 |
| A | TYR84 |
| A | HOH2058 |
| A | HOH2059 |
| A | HOH2222 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1476 |
| Chain | Residue |
| A | ASN135 |
| A | ILE136 |
| A | GLU137 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1477 |
| Chain | Residue |
| A | PHE48 |
| A | ASP324 |
| A | TYR367 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1478 |
| Chain | Residue |
| A | THR311 |
| A | GLY312 |
| A | TYR313 |
| A | PHE338 |
| A | ARG348 |
| A | ARG366 |
| A | HOH2269 |
| A | HOH2279 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1479 |
| Chain | Residue |
| A | SER123 |
| A | PRO124 |
| A | TYR189 |
| A | HOH2138 |
| A | HOH2280 |
| A | HOH2281 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD A 1480 |
| Chain | Residue |
| A | HIS37 |
| A | HIS54 |
| A | LEU246 |
| A | ARG337 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRS B 1471 |
| Chain | Residue |
| B | HIS37 |
| B | ASP38 |
| B | TRP100 |
| B | VAL170 |
| B | ASP171 |
| B | GLU224 |
| B | LEU246 |
| B | HIS318 |
| B | MRD1481 |
| B | HOH2013 |
| B | HOH2300 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1472 |
| Chain | Residue |
| B | TRP93 |
| B | ARG125 |
| B | MET151 |
| B | GLU152 |
| B | HOH2301 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 1473 |
| Chain | Residue |
| B | HIS318 |
| B | HOH2012 |
| B | HOH2014 |
| B | HOH2016 |
| B | HOH2105 |
| B | HOH2148 |
| B | HOH2203 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1474 |
| Chain | Residue |
| B | ASP103 |
| B | VAL104 |
| B | THR105 |
| B | HOH2018 |
| B | HOH2036 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1475 |
| Chain | Residue |
| B | VAL73 |
| B | TYR84 |
| B | HOH2060 |
| B | HOH2061 |
| B | HOH2241 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1476 |
| Chain | Residue |
| B | THR311 |
| B | GLY312 |
| B | TYR313 |
| B | ARG348 |
| B | ARG366 |
| B | HOH2200 |
| B | HOH2291 |
| B | HOH2302 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1477 |
| Chain | Residue |
| B | LYS434 |
| B | LYS435 |
| B | ASN459 |
| B | THR460 |
| B | SER461 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1478 |
| Chain | Residue |
| B | HOH2280 |
| B | HOH2303 |
| B | PHE353 |
| B | MET354 |
| B | LEU372 |
| B | HOH2209 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1479 |
| Chain | Residue |
| B | ASP324 |
| B | TYR367 |
| B | HOH2304 |
| site_id | CC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 1480 |
| Chain | Residue |
| B | GLU43 |
| B | THR44 |
| B | ASN45 |
| B | GLN106 |
| B | GLY413 |
| B | GLU414 |
| B | MET415 |
| B | THR416 |
| B | HOH2305 |
| B | HOH2306 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD B 1481 |
| Chain | Residue |
| B | HIS37 |
| B | HIS54 |
| B | ARG337 |
| B | TRS1471 |
Functional Information from PROSITE/UniProt
| site_id | PS00867 |
| Number of Residues | 8 |
| Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. ILEMNPKT |
| Chain | Residue | Details |
| A | ILE195-THR202 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ASP38 | |
| A | ASP38 | |
| Chain | Residue | Details |
| A | GLU224 | |
| B | GLU224 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN168 | |
| B | ASP38 | |
| B | ASP122 | |
| B | ASN168 | |
| A | ASP38 | |
| A | ASP122 | |
| Chain | Residue | Details |
| A | SER188 | |
| B | SER188 | |
| Chain | Residue | Details |
| A | HIS220 | |
| B | HIS220 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS318 | |
| B | HIS318 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate => ECO:0000305|PubMed:20883454 |
| Chain | Residue | Details |
| A | ASP171 | |
| B | ASP171 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Important for substrate recognition |
| Chain | Residue | Details |
| A | HIS318 | |
| B | HIS318 | |
