2X7V

Crystal structure of Thermotoga maritima endonuclease IV in the presence of zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008270	molecular_function	zinc ion binding
A	0008833	molecular_function	deoxyribonuclease IV (phage-T4-induced) activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1287

Chain	Residue
A	HIS69
A	HIS109
A	GLU144
A	ZN1288
A	HOH2164

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 1288

Chain	Residue
A	GLU260
A	ZN1287
A	HOH2164
A	GLU144
A	ASP178
A	HIS181
A	HIS215

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1289

Chain	Residue
A	HIS181
A	ASP228
A	HIS230
A	HOH2165

---

Functional Information from PROSITE/UniProt

site_id	PS00729
Number of Residues	9
Details	AP_NUCLEASE_F2_1 AP endonucleases family 2 signature 1. HSgYLINLA

Chain	Residue	Details
A	HIS69-ALA77

---

site_id	PS00730
Number of Residues	8
Details	AP_NUCLEASE_F2_2 AP endonucleases family 2 signature 2. AITYDTCH

Chain	Residue	Details
A	ALA174-HIS181

---

site_id	PS00731
Number of Residues	17
Details	AP_NUCLEASE_F2_3 AP endonucleases family 2 signature 3. IHlNDSkyplGaakDrH

Chain	Residue	Details
A	ILE214-HIS230

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00152

Chain	Residue	Details
A	HIS69
A	HIS109
A	GLU144
A	ASP178
A	HIS181
A	HIS215
A	ASP228
A	HIS230
A	GLU260

---