2X7G

Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PVB A 800

Chain	Residue
A	LEU98
A	TYR239
A	EDO1708
A	TRP100
A	GLY101
A	ALA119
A	GLU178
A	LEU180
A	HIS182
A	HIS183
A	LEU232

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1700

Chain	Residue
A	TYR593
A	ARG632
A	ASN636
A	ARG637
A	ARG642
A	HOH2027
A	HOH2105
A	HOH2106

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1701

Chain	Residue
A	SER687
A	GLY689
A	ARG693
A	HOH2107

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1702

Chain	Residue
A	GLY101
A	HIS102
A	PHE103
A	SER104

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1703

Chain	Residue
A	ARG559
A	ARG562
A	ARG605
A	HOH2108

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1704

Chain	Residue
A	HIS598
A	SER599
A	ARG605
A	ARG622

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1705

Chain	Residue
A	ARG622
A	HIS623

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1706

Chain	Residue
A	ARG605
A	ARG637
A	ARG638
A	ACT1707
A	HOH2109

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 1707

Chain	Residue
A	GLN560
A	ARG637
A	SO41706

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1708

Chain	Residue
A	GLU136
A	ALA540
A	ASP541
A	LEU542
A	PVB800

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1709

Chain	Residue
A	ASP150
A	ASN152
A	ASP213
A	HOH2110

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1710

Chain	Residue
A	SER166
A	SER651
A	PHE653
A	THR671
A	EDO1713
A	HOH2111

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1711

Chain	Residue
A	LEU594
A	HOH2094

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1712

Chain	Residue
A	PHE163
A	LYS164
A	PRO649
A	TRP650
A	SER651
A	ASP654
A	EDO1713

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1713

Chain	Residue
A	LYS164
A	LEU616
A	PRO649
A	EDO1710
A	EDO1712

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlCwdmqgkrf..........VAMK

Chain	Residue	Details
A	LEU98-LYS121

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILM

Chain	Residue	Details
A	ILE221-MET233

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UPE1","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage; by caspase-3","evidences":[{"source":"PubMed","id":"21056976","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---