Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2X6T

AGME bound to ADP-B-mannose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0050661	molecular_function	NADP binding
A	0070401	molecular_function	NADP+ binding
A	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0016020	cellular_component	membrane
B	0016853	molecular_function	isomerase activity
B	0050661	molecular_function	NADP binding
B	0070401	molecular_function	NADP+ binding
B	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0009244	biological_process	lipopolysaccharide core region biosynthetic process
C	0016020	cellular_component	membrane
C	0016853	molecular_function	isomerase activity
C	0050661	molecular_function	NADP binding
C	0070401	molecular_function	NADP+ binding
C	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
D	0009103	biological_process	lipopolysaccharide biosynthetic process
D	0009244	biological_process	lipopolysaccharide core region biosynthetic process
D	0016020	cellular_component	membrane
D	0016853	molecular_function	isomerase activity
D	0050661	molecular_function	NADP binding
D	0070401	molecular_function	NADP+ binding
D	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
E	0009103	biological_process	lipopolysaccharide biosynthetic process
E	0009244	biological_process	lipopolysaccharide core region biosynthetic process
E	0016020	cellular_component	membrane
E	0016853	molecular_function	isomerase activity
E	0050661	molecular_function	NADP binding
E	0070401	molecular_function	NADP+ binding
E	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
F	0009103	biological_process	lipopolysaccharide biosynthetic process
F	0009244	biological_process	lipopolysaccharide core region biosynthetic process
F	0016020	cellular_component	membrane
F	0016853	molecular_function	isomerase activity
F	0050661	molecular_function	NADP binding
F	0070401	molecular_function	NADP+ binding
F	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
G	0009103	biological_process	lipopolysaccharide biosynthetic process
G	0009244	biological_process	lipopolysaccharide core region biosynthetic process
G	0016020	cellular_component	membrane
G	0016853	molecular_function	isomerase activity
G	0050661	molecular_function	NADP binding
G	0070401	molecular_function	NADP+ binding
G	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
H	0009103	biological_process	lipopolysaccharide biosynthetic process
H	0009244	biological_process	lipopolysaccharide core region biosynthetic process
H	0016020	cellular_component	membrane
H	0016853	molecular_function	isomerase activity
H	0050661	molecular_function	NADP binding
H	0070401	molecular_function	NADP+ binding
H	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0005975	biological_process	carbohydrate metabolic process
I	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
I	0009103	biological_process	lipopolysaccharide biosynthetic process
I	0009244	biological_process	lipopolysaccharide core region biosynthetic process
I	0016020	cellular_component	membrane
I	0016853	molecular_function	isomerase activity
I	0050661	molecular_function	NADP binding
I	0070401	molecular_function	NADP+ binding
I	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0005975	biological_process	carbohydrate metabolic process
J	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
J	0009103	biological_process	lipopolysaccharide biosynthetic process
J	0009244	biological_process	lipopolysaccharide core region biosynthetic process
J	0016020	cellular_component	membrane
J	0016853	molecular_function	isomerase activity
J	0050661	molecular_function	NADP binding
J	0070401	molecular_function	NADP+ binding
J	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:17316025

Chain	Residue	Details
A	PHE140
A	LYS178
B	PHE140
B	LYS178
C	PHE140
C	LYS178
D	PHE140
D	LYS178
E	PHE140
E	LYS178
F	PHE140
F	LYS178
G	PHE140
G	LYS178
H	PHE140
H	LYS178
I	PHE140
I	LYS178
J	PHE140
J	LYS178

site_id	SWS_FT_FI2
Number of Residues	150
Details	BINDING: BINDING => ECO:0000269\|PubMed:10896473

Chain	Residue	Details
B	ASN92
B	LYS144
B	ASN169
B	VAL170
B	LYS178
B	SER180
B	HIS187
B	PHE201
B	ARG209
B	TYR272
C	PHE10
C	ASP31
C	LYS38
C	LYS53
C	GLU75
C	ASN92
C	LYS144
C	ASN169
C	VAL170
C	LYS178
C	SER180
C	HIS187
C	PHE201
C	ARG209
C	TYR272
D	PHE10
D	ASP31
D	LYS38
D	LYS53
D	GLU75
D	ASN92
D	LYS144
D	ASN169
D	VAL170
D	LYS178
D	SER180
D	HIS187
D	PHE201
D	ARG209
D	TYR272
E	PHE10
E	ASP31
E	LYS38
E	LYS53
E	GLU75
E	ASN92
E	LYS144
E	ASN169
E	VAL170
E	LYS178
E	SER180
E	HIS187
E	PHE201
E	ARG209
E	TYR272
F	PHE10
F	ASP31
F	LYS38
F	LYS53
F	GLU75
F	ASN92
F	LYS144
F	ASN169
F	VAL170
F	LYS178
F	SER180
F	HIS187
F	PHE201
F	ARG209
F	TYR272
G	PHE10
G	ASP31
G	LYS38
G	LYS53
G	GLU75
G	ASN92
G	LYS144
G	ASN169
G	VAL170
G	LYS178
G	SER180
G	HIS187
G	PHE201
G	ARG209
G	TYR272
H	PHE10
H	ASP31
H	LYS38
H	LYS53
H	GLU75
H	ASN92
H	LYS144
H	ASN169
H	VAL170
H	LYS178
H	SER180
H	HIS187
H	PHE201
H	ARG209
H	TYR272
I	PHE10
I	ASP31
I	LYS38
I	LYS53
I	GLU75
I	ASN92
I	LYS144
I	ASN169
I	VAL170
I	LYS178
I	SER180
I	HIS187
I	PHE201
I	ARG209
I	TYR272
J	PHE10
J	ASP31
J	LYS38
J	LYS53
J	GLU75
J	ASN92
J	LYS144
J	ASN169
J	VAL170
J	LYS178
J	SER180
J	HIS187
J	PHE201
J	ARG209
J	TYR272
A	PHE10
A	ASP31
A	LYS38
A	LYS53
A	GLU75
A	ASN92
A	LYS144
A	ASN169
A	VAL170
A	LYS178
A	SER180
A	HIS187
A	PHE201
A	ARG209
A	TYR272
B	PHE10
B	ASP31
B	LYS38
B	LYS53
B	GLU75

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18723842

Chain	Residue	Details
A	LYS267
B	LYS267
C	LYS267
D	LYS267
E	LYS267
F	LYS267
G	LYS267
H	LYS267
I	LYS267
J	LYS267

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
A	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
A	PHE140	proton acceptor, proton donor
A	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
B	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
B	PHE140	proton acceptor, proton donor
B	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
C	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
C	PHE140	proton acceptor, proton donor
C	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
D	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
D	PHE140	proton acceptor, proton donor
D	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA5
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
E	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
E	PHE140	proton acceptor, proton donor
E	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA6
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
F	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
F	PHE140	proton acceptor, proton donor
F	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA7
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
G	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
G	PHE140	proton acceptor, proton donor
G	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA8
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
H	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
H	PHE140	proton acceptor, proton donor
H	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA9
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
I	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
I	LYS178	electrostatic stabiliser, proton acceptor, proton donor
I	PHE140	proton acceptor, proton donor

site_id	MCSA10
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
J	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
J	PHE140	proton acceptor, proton donor
J	LYS178	electrostatic stabiliser, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)