Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2X6T

AGME bound to ADP-B-mannose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0050661	molecular_function	NADP binding
A	0070401	molecular_function	NADP+ binding
A	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0016020	cellular_component	membrane
B	0016853	molecular_function	isomerase activity
B	0050661	molecular_function	NADP binding
B	0070401	molecular_function	NADP+ binding
B	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0009244	biological_process	lipopolysaccharide core region biosynthetic process
C	0016020	cellular_component	membrane
C	0016853	molecular_function	isomerase activity
C	0050661	molecular_function	NADP binding
C	0070401	molecular_function	NADP+ binding
C	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
D	0009103	biological_process	lipopolysaccharide biosynthetic process
D	0009244	biological_process	lipopolysaccharide core region biosynthetic process
D	0016020	cellular_component	membrane
D	0016853	molecular_function	isomerase activity
D	0050661	molecular_function	NADP binding
D	0070401	molecular_function	NADP+ binding
D	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
E	0009103	biological_process	lipopolysaccharide biosynthetic process
E	0009244	biological_process	lipopolysaccharide core region biosynthetic process
E	0016020	cellular_component	membrane
E	0016853	molecular_function	isomerase activity
E	0050661	molecular_function	NADP binding
E	0070401	molecular_function	NADP+ binding
E	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
F	0009103	biological_process	lipopolysaccharide biosynthetic process
F	0009244	biological_process	lipopolysaccharide core region biosynthetic process
F	0016020	cellular_component	membrane
F	0016853	molecular_function	isomerase activity
F	0050661	molecular_function	NADP binding
F	0070401	molecular_function	NADP+ binding
F	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
G	0009103	biological_process	lipopolysaccharide biosynthetic process
G	0009244	biological_process	lipopolysaccharide core region biosynthetic process
G	0016020	cellular_component	membrane
G	0016853	molecular_function	isomerase activity
G	0050661	molecular_function	NADP binding
G	0070401	molecular_function	NADP+ binding
G	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
H	0009103	biological_process	lipopolysaccharide biosynthetic process
H	0009244	biological_process	lipopolysaccharide core region biosynthetic process
H	0016020	cellular_component	membrane
H	0016853	molecular_function	isomerase activity
H	0050661	molecular_function	NADP binding
H	0070401	molecular_function	NADP+ binding
H	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0005975	biological_process	carbohydrate metabolic process
I	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
I	0009103	biological_process	lipopolysaccharide biosynthetic process
I	0009244	biological_process	lipopolysaccharide core region biosynthetic process
I	0016020	cellular_component	membrane
I	0016853	molecular_function	isomerase activity
I	0050661	molecular_function	NADP binding
I	0070401	molecular_function	NADP+ binding
I	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0005975	biological_process	carbohydrate metabolic process
J	0008712	molecular_function	ADP-glyceromanno-heptose 6-epimerase activity
J	0009103	biological_process	lipopolysaccharide biosynthetic process
J	0009244	biological_process	lipopolysaccharide core region biosynthetic process
J	0016020	cellular_component	membrane
J	0016853	molecular_function	isomerase activity
J	0050661	molecular_function	NADP binding
J	0070401	molecular_function	NADP+ binding
J	0097171	biological_process	ADP-L-glycero-beta-D-manno-heptose biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01601","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	200
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01601","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01601","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
A	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
A	PHE140	proton acceptor, proton donor
A	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA10
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
J	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
J	PHE140	proton acceptor, proton donor
J	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
B	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
B	PHE140	proton acceptor, proton donor
B	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
C	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
C	PHE140	proton acceptor, proton donor
C	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
D	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
D	PHE140	proton acceptor, proton donor
D	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA5
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
E	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
E	PHE140	proton acceptor, proton donor
E	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA6
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
F	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
F	PHE140	proton acceptor, proton donor
F	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA7
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
G	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
G	PHE140	proton acceptor, proton donor
G	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA8
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
H	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
H	PHE140	proton acceptor, proton donor
H	LYS178	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA9
Number of Residues	3
Details	M-CSA 557

Chain	Residue	Details
I	SER116	electrostatic stabiliser, proton acceptor, proton donor, proton relay
I	PHE140	proton acceptor, proton donor
I	LYS178	electrostatic stabiliser, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)