2X5J

Crystal structure of the Apoform of the D-Erythrose-4-phosphate dehydrogenase from E. coli

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0008615	biological_process	pyridoxine biosynthetic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0042823	biological_process	pyridoxal phosphate biosynthetic process
O	0048001	molecular_function	erythrose-4-phosphate dehydrogenase activity
O	0051287	molecular_function	NAD binding
O	0072524	biological_process	pyridine-containing compound metabolic process
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0008615	biological_process	pyridoxine biosynthetic process
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0042823	biological_process	pyridoxal phosphate biosynthetic process
P	0048001	molecular_function	erythrose-4-phosphate dehydrogenase activity
P	0051287	molecular_function	NAD binding
P	0072524	biological_process	pyridine-containing compound metabolic process
Q	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006006	biological_process	glucose metabolic process
Q	0008615	biological_process	pyridoxine biosynthetic process
Q	0016491	molecular_function	oxidoreductase activity
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0042823	biological_process	pyridoxal phosphate biosynthetic process
Q	0048001	molecular_function	erythrose-4-phosphate dehydrogenase activity
Q	0051287	molecular_function	NAD binding
Q	0072524	biological_process	pyridine-containing compound metabolic process
R	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006006	biological_process	glucose metabolic process
R	0008615	biological_process	pyridoxine biosynthetic process
R	0016491	molecular_function	oxidoreductase activity
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0042823	biological_process	pyridoxal phosphate biosynthetic process
R	0048001	molecular_function	erythrose-4-phosphate dehydrogenase activity
R	0051287	molecular_function	NAD binding
R	0072524	biological_process	pyridine-containing compound metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 O 1600

Chain	Residue
O	THR150
O	HIS176
O	THR208
O	LYS209
O	HOH2136

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 P 1600

Chain	Residue
P	LEU210
P	HOH2109
P	THR150
P	HIS176
P	THR208
P	LYS209

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 Q 1600

Chain	Residue
Q	THR150
Q	HIS176
Q	THR208
Q	LYS209
Q	HOH2097
Q	HOH2146

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 R 1600

Chain	Residue
R	THR150
R	HIS176
R	THR208
R	LYS209
R	LEU210
R	HOH2145
R	HOH2146
R	HOH2147
R	HOH2148

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcI

Chain	Residue	Details
O	ALA147-ILE154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Activates thiol group during catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---