Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2X4M

Yersinia Pestis Plasminogen Activator Pla

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0009279	cellular_component	cell outer membrane
B	0004175	molecular_function	endopeptidase activity
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0009279	cellular_component	cell outer membrane
C	0004175	molecular_function	endopeptidase activity
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0009279	cellular_component	cell outer membrane
D	0004175	molecular_function	endopeptidase activity
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0009279	cellular_component	cell outer membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1295

Chain	Residue
A	THR236
A	ASN238
A	TYR290

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1296

Chain	Residue
A	ARG171
A	HIS203
A	ASN205
A	ARG216
A	HOH2032

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1297

Chain	Residue
A	ARG70
A	GLU111
A	ASP113
A	GLN135
A	LYS195
A	LYS54

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1298

Chain	Residue
A	ALA103
A	GLY145
A	GLY146
A	LYS161
A	HOH2012

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1299

Chain	Residue
A	ASP84
A	TYR150
A	HIS208
A	ARG211
A	C8E1304
A	HOH2033

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE C8E A 1300

Chain	Residue
A	ILE57
A	ARG70
A	TYR112

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE C8E A 1301

Chain	Residue
A	LEU53
A	TRP72
A	ASN110
A	ARG138

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE C8E A 1302

Chain	Residue
A	TYR126
A	LYS127
A	GLY181
A	GLN182
C	LEU121
C	ASP123

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE C8E A 1303

Chain	Residue
A	PRO175
A	TYR176
A	ILE177
A	TRP199

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE C8E A 1304

Chain	Residue
A	MET30
A	HIS208
A	GLU217
A	SO41299

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1299

Chain	Residue
A	SER3
B	ALA103
B	GLY146
B	LYS161
B	HOH2013

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1300

Chain	Residue
B	LYS249
B	ASP251
B	GLU252

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1301

Chain	Residue
B	ARG171
B	HIS203
B	ASN205
B	ARG216

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1302

Chain	Residue
B	ASP97
B	SO41303

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1303

Chain	Residue
B	ASP84
B	HIS208
B	ARG211
B	SO41302
B	C8E1304

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE C8E B 1304

Chain	Residue
B	GLU29
B	MET30
B	GLU217
B	ALA275
B	SO41303

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE C8E B 1305

Chain	Residue
B	LEU53
B	GLY71
B	TRP72
B	ASN110
B	GLU111

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE C8E B 1306

Chain	Residue
B	LEU179
B	ALA180
B	GLY181
B	ALA192
B	LEU193
B	PHE194
B	THR227

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1294

Chain	Residue
C	LYS54
C	ARG70
C	GLU111
C	ASP113
C	GLN135
C	LYS195
C	VAL228
C	THR246

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1295

Chain	Residue
B	GLN92
B	SER93
B	GLU94
C	ASN125
C	TYR126
C	TYR183
C	ILE185

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1296

Chain	Residue
C	ARG211
C	ASP84
C	HIS208

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1297

Chain	Residue
C	ARG171
C	HIS203
C	ASN205
C	ARG216

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1298

Chain	Residue
A	GLY162
A	VAL163
A	ARG164
C	VAL163
C	ARG164

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1299

Chain	Residue
C	ALA103
C	GLY145
C	GLY146
C	LYS161
D	SER3

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE C8E C 1300

Chain	Residue
C	MET30
C	HIS208
C	GLU217

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE C8E C 1301

Chain	Residue
C	LEU53
C	GLY71
C	ASN110

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE C8E C 1302

Chain	Residue
C	ALA69
C	TYR112

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 1295

Chain	Residue
D	LYS54
D	ARG70
D	GLU111
D	ASP113
D	LYS195
D	VAL228
D	THR246
D	HOH2026

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1296

Chain	Residue
D	GLY145
D	GLY146
D	LYS161
D	HOH2009
D	HOH2012

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1297

Chain	Residue
D	ARG171
D	SER173
D	ARG201
D	HIS203

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1298

Chain	Residue
D	ARG171
D	HIS203
D	ASN205

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1299

Chain	Residue
D	THR236
D	TYR290
D	HOH2027

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1300

Chain	Residue
B	VAL163
B	ARG164
D	ARG164

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1301

Chain	Residue
D	ASP84
D	HIS208
D	ARG211
D	C8E1304
D	HOH2007

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE C8E D 1302

Chain	Residue
D	LYS54
D	GLY55
D	TRP72
D	ASN110
D	GLU111

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE C8E D 1303

Chain	Residue
D	GLY55
D	ASP56
D	ALA69
D	ARG70
D	TYR112

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE C8E D 1304

Chain	Residue
D	GLU29
D	HIS208
D	ARG211
D	SO41301

Functional Information from PROSITE/UniProt

site_id	PS00834
Number of Residues	10
Details	OMPTIN_1 Aspartyl proteases, omptin family signature 1. WTDhSsHPaT

Chain	Residue	Details
A	TRP95-THR104

site_id	PS00835
Number of Residues	17
Details	OMPTIN_2 Aspartyl proteases, omptin family signature 2. AGYQETRFSWTAtGGSY

Chain	Residue	Details
A	ALA132-TYR148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	ALA1-PRO11
B	THR236-ASN238
C	ALA1-PRO11
C	PRO61-PHE64
C	LEU121-ASN125
C	ILE185-ASP187
C	THR236-ASN238
D	ALA1-PRO11
D	PRO61-PHE64
D	LEU121-ASN125
D	ILE185-ASP187
A	PRO61-PHE64
D	THR236-ASN238
A	LEU121-ASN125
A	ILE185-ASP187
A	THR236-ASN238
B	ALA1-PRO11
B	PRO61-PHE64
B	LEU121-ASN125
B	ILE185-ASP187

site_id	SWS_FT_FI2
Number of Residues	32
Details	TRANSMEM: Beta stranded; Name=1 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	ASP12-THR20
B	ASP12-THR20
C	ASP12-THR20
D	ASP12-THR20

site_id	SWS_FT_FI3
Number of Residues	656
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	GLY21-VAL50
B	SER248-ASN281
C	GLY21-VAL50
C	LEU75-GLU111
C	GLN135-MET174
C	SER197-TYR224
C	SER248-ASN281
D	GLY21-VAL50
D	LEU75-GLU111
D	GLN135-MET174
D	SER197-TYR224
A	LEU75-GLU111
D	SER248-ASN281
A	GLN135-MET174
A	SER197-TYR224
A	SER248-ASN281
B	GLY21-VAL50
B	LEU75-GLU111
B	GLN135-MET174
B	SER197-TYR224

site_id	SWS_FT_FI4
Number of Residues	36
Details	TRANSMEM: Beta stranded; Name=2 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	ALA51-ASP60
B	ALA51-ASP60
C	ALA51-ASP60
D	ALA51-ASP60

site_id	SWS_FT_FI5
Number of Residues	36
Details	TRANSMEM: Beta stranded; Name=3 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	LEU65-SER74
B	LEU65-SER74
C	LEU65-SER74
D	LEU65-SER74

site_id	SWS_FT_FI6
Number of Residues	32
Details	TRANSMEM: Beta stranded; Name=4 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	TYR112-LEU120
B	TYR112-LEU120
C	TYR112-LEU120
D	TYR112-LEU120

site_id	SWS_FT_FI7
Number of Residues	32
Details	TRANSMEM: Beta stranded; Name=5 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	TYR126-TYR134
B	TYR126-TYR134
C	TYR126-TYR134
D	TYR126-TYR134

site_id	SWS_FT_FI8
Number of Residues	36
Details	TRANSMEM: Beta stranded; Name=6 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	PRO175-ARG184
B	PRO175-ARG184
C	PRO175-ARG184
D	PRO175-ARG184

site_id	SWS_FT_FI9
Number of Residues	32
Details	TRANSMEM: Beta stranded; Name=7 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	PHE188-PHE196
B	PHE188-PHE196
C	PHE188-PHE196
D	PHE188-PHE196

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Beta stranded; Name=8 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	TYR225-VAL235
B	TYR225-VAL235
C	TYR225-VAL235
D	TYR225-VAL235

site_id	SWS_FT_FI11
Number of Residues	32
Details	TRANSMEM: Beta stranded; Name=9 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	ALA239-TYR247
B	ALA239-TYR247
C	ALA239-TYR247
D	ALA239-TYR247

site_id	SWS_FT_FI12
Number of Residues	40
Details	TRANSMEM: Beta stranded; Name=10 => ECO:0000269\|PubMed:20637417

Chain	Residue	Details
A	TYR282-PHE292
B	TYR282-PHE292
C	TYR282-PHE292
D	TYR282-PHE292

site_id	SWS_FT_FI13
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:17635705, ECO:0000305\|PubMed:20637417

Chain	Residue	Details
A	ASP84
B	ASP84
C	ASP84
D	ASP84

site_id	SWS_FT_FI14
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:20637417

Chain	Residue	Details
A	ALA86
D	ALA86
D	ASP206
D	HIS208
A	ASP206
A	HIS208
B	ALA86
B	ASP206
B	HIS208
C	ALA86
C	ASP206
C	HIS208

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)