2WYO
Trypanosoma brucei glutathione synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004363 | molecular_function | glutathione synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006750 | biological_process | glutathione biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0043295 | molecular_function | glutathione binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004363 | molecular_function | glutathione synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006750 | biological_process | glutathione biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0043295 | molecular_function | glutathione binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004363 | molecular_function | glutathione synthase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006750 | biological_process | glutathione biosynthetic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0043295 | molecular_function | glutathione binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004363 | molecular_function | glutathione synthase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005730 | cellular_component | nucleolus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006750 | biological_process | glutathione biosynthetic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0043295 | molecular_function | glutathione binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GSH D 1556 |
| Chain | Residue |
| D | ARG119 |
| D | ARG324 |
| D | TYR327 |
| D | ARG530 |
| D | GLY540 |
| D | VAL541 |
| D | MET542 |
| D | ILE147 |
| D | SER148 |
| D | SER150 |
| D | PHE151 |
| D | GLN261 |
| D | GLU264 |
| D | ASN266 |
| D | GLN270 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GSH B 1556 |
| Chain | Residue |
| B | ARG119 |
| B | SER148 |
| B | CYS149 |
| B | SER150 |
| B | PHE151 |
| B | GLN261 |
| B | GLU264 |
| B | ASN266 |
| B | GLN270 |
| B | ARG324 |
| B | TYR327 |
| B | ARG530 |
| B | GLY540 |
| B | VAL541 |
| B | MET542 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GSH A 1556 |
| Chain | Residue |
| A | ARG119 |
| A | SER148 |
| A | SER150 |
| A | PHE151 |
| A | GLN261 |
| A | GLU264 |
| A | ASN266 |
| A | ARG324 |
| A | TYR327 |
| A | ARG530 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GSH C 1556 |
| Chain | Residue |
| C | ARG119 |
| C | ILE147 |
| C | SER148 |
| C | SER150 |
| C | GLN261 |
| C | ARG265 |
| C | ASN266 |
| C | ARG324 |
| C | TYR327 |
| C | ARG530 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1557 |
| Chain | Residue |
| B | GLU53 |
| B | THR56 |
| B | ARG138 |
| B | ARG393 |
| B | HIS394 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1557 |
| Chain | Residue |
| A | PHE-3 |
| A | GLY-1 |
| A | GLN-2 |
| A | SER476 |
| A | THR477 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1558 |
| Chain | Residue |
| A | GLU53 |
| A | THR56 |
| A | SER137 |
| A | ARG393 |
| A | HIS394 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1557 |
| Chain | Residue |
| C | MET29 |
| C | LYS30 |
| C | ARG265 |
| C | ASN266 |
| C | THR267 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1558 |
| Chain | Residue |
| C | GLY10 |
| C | ALA11 |
| C | GLU12 |
| C | ARG13 |
| D | ARG284 |
| D | ILE286 |
| D | ARG288 |
| D | TYR316 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1557 |
| Chain | Residue |
| D | ARG13 |
| D | TYR14 |
| D | ALA15 |
| D | GLU16 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1559 |
| Chain | Residue |
| C | GLU53 |
| C | THR56 |
| C | SER137 |
| C | ARG138 |
| C | ARG393 |
