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2WWP

Crystal structure of the human lipocalin-type prostaglandin D synthase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0004667molecular_functionprostaglandin-D synthase activity
A0005501molecular_functionretinoid binding
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005791cellular_componentrough endoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0010467biological_processgene expression
A0016020cellular_componentmembrane
A0016853molecular_functionisomerase activity
A0019371biological_processcyclooxygenase pathway
A0031965cellular_componentnuclear membrane
A0036094molecular_functionsmall molecule binding
A0043303biological_processmast cell degranulation
A0045187biological_processregulation of circadian sleep/wake cycle, sleep
A0048471cellular_componentperinuclear region of cytoplasm
A0051384biological_processresponse to glucocorticoid
A0070062cellular_componentextracellular exosome
A2000255biological_processnegative regulation of male germ cell proliferation
B0001516biological_processprostaglandin biosynthetic process
B0004667molecular_functionprostaglandin-D synthase activity
B0005501molecular_functionretinoid binding
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005791cellular_componentrough endoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0010467biological_processgene expression
B0016020cellular_componentmembrane
B0016853molecular_functionisomerase activity
B0019371biological_processcyclooxygenase pathway
B0031965cellular_componentnuclear membrane
B0036094molecular_functionsmall molecule binding
B0043303biological_processmast cell degranulation
B0045187biological_processregulation of circadian sleep/wake cycle, sleep
B0048471cellular_componentperinuclear region of cytoplasm
B0051384biological_processresponse to glucocorticoid
B0070062cellular_componentextracellular exosome
B2000255biological_processnegative regulation of male germ cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 1185
ChainResidue
ALEU159

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SCN A 1186
ChainResidue
AGLN36
AASP37

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SCN B 1183
ChainResidue
BGLN36
BASP37

Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFQqdKFLGRWFSA
ChainResidueDetails
AASN33-ALA46

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:20667974
ChainResidueDetails
ACYS65
BCYS65

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:23234360
ChainResidueDetails
ASER29
BSER29

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:8336134
ChainResidueDetails
AASN51
BASN51

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:8336134
ChainResidueDetails
AASN78
BASN78

226707

PDB entries from 2024-10-30

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