2WVT
Crystal structure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron in complex with a novel iminosugar fucosidase inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004560 | molecular_function | alpha-L-fucosidase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0015928 | molecular_function | fucosidase activity |
| A | 0016139 | biological_process | glycoside catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0004560 | molecular_function | alpha-L-fucosidase activity |
| B | 0005764 | cellular_component | lysosome |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0015928 | molecular_function | fucosidase activity |
| B | 0016139 | biological_process | glycoside catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FHN A 1473 |
| Chain | Residue |
| A | HIS66 |
| A | GLU288 |
| A | CYS308 |
| A | TRP316 |
| A | GLU87 |
| A | TRP88 |
| A | HIS135 |
| A | HIS136 |
| A | TYR178 |
| A | TRP227 |
| A | ASP229 |
| A | ARG262 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FHN B 1474 |
| Chain | Residue |
| B | HIS66 |
| B | GLU87 |
| B | TRP88 |
| B | HIS135 |
| B | HIS136 |
| B | TYR178 |
| B | TRP227 |
| B | ASP229 |
| B | ARG262 |
| B | GLU288 |
| B | CYS308 |
| B | TRP316 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1474 |
| Chain | Residue |
| A | TRP232 |
| A | ARG262 |
| A | ARG271 |
| A | HIS272 |
| A | GLY286 |
| A | HOH2214 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1475 |
| Chain | Residue |
| A | GLU284 |
| A | GLY286 |
| A | TYR287 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1475 |
| Chain | Residue |
| B | ALA85 |
| B | GLU87 |
| B | TRP88 |
| B | ASN314 |
| B | TRP316 |
| B | HOH2131 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1476 |
| Chain | Residue |
| A | ASP393 |
| B | VAL295 |
| B | LYS391 |
| B | GLN392 |
| B | ASP393 |
| B | HOH2241 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1477 |
| Chain | Residue |
| A | ASP393 |
| B | ASP335 |
| B | LYS391 |
| B | GLY395 |
| B | TYR396 |
| B | ASN411 |
| B | HOH2211 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IMD A 1477 |
| Chain | Residue |
| A | LYS456 |
| A | LYS457 |
| A | ASN458 |
| A | HOH2208 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD B 1479 |
| Chain | Residue |
| B | LYS90 |
| B | SER91 |
| B | TYR191 |
