2WVB

Structural and mechanistic insights into Helicobacter pylori NikR function

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010045	biological_process	response to nickel cation
A	0016151	molecular_function	nickel cation binding
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010045	biological_process	response to nickel cation
B	0016151	molecular_function	nickel cation binding
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1143

Chain	Residue
A	GLU78
A	ARG82
A	GLY129
A	LEU130
A	ARG131
A	FMT1145
A	FMT1145
A	HOH2074

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1144

Chain	Residue
A	ARG82
A	ARG82
A	ILE86
A	HOH2082
A	HOH2082
A	HOH2083
B	ARG77
A	GLU78

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FMT A 1145

Chain	Residue
A	GLN76
A	GLN76
A	ARG82
A	ARG82
A	ARG131
A	ARG131
A	GOL1143
A	GOL1143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00476","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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