Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WSX

Crystal Structure of Carnitine Transporter from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0009437	biological_process	carnitine metabolic process
A	0015226	molecular_function	carnitine transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015879	biological_process	carnitine transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0044667	molecular_function	(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
A	0071705	biological_process	nitrogen compound transport
A	1900749	biological_process	(R)-carnitine transport
A	1900751	biological_process	4-(trimethylammonio)butanoate transport
A	1902270	biological_process	(R)-carnitine transmembrane transport
A	1902603	biological_process	carnitine transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0009437	biological_process	carnitine metabolic process
B	0015226	molecular_function	carnitine transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015879	biological_process	carnitine transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0044667	molecular_function	(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
B	0071705	biological_process	nitrogen compound transport
B	1900749	biological_process	(R)-carnitine transport
B	1900751	biological_process	4-(trimethylammonio)butanoate transport
B	1902270	biological_process	(R)-carnitine transmembrane transport
B	1902603	biological_process	carnitine transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0009437	biological_process	carnitine metabolic process
C	0015226	molecular_function	carnitine transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015879	biological_process	carnitine transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0044667	molecular_function	(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
C	0071705	biological_process	nitrogen compound transport
C	1900749	biological_process	(R)-carnitine transport
C	1900751	biological_process	4-(trimethylammonio)butanoate transport
C	1902270	biological_process	(R)-carnitine transmembrane transport
C	1902603	biological_process	carnitine transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NM2 A 1504

Chain	Residue
A	TRP142
A	TRP323
A	TYR327
A	MET331

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NM2 A 1505

Chain	Residue
A	GLY311
A	PHE312
A	GLY315
A	LEU469
A	GLN473

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NM2 B 1504

Chain	Residue
B	TRP142
B	TRP323
B	TYR327
B	MET331

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NM2 B 1505

Chain	Residue
B	TYR114
B	GLY311
B	PHE312
B	GLY315
B	GLN473

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NM2 C 1504

Chain	Residue
C	TRP142
C	TRP323
C	TYR327
C	MET331

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NM2 C 1505

Chain	Residue
C	TYR114
C	GLY311
C	PHE312
C	GLY315
C	LEU469
C	GLN473

Functional Information from PROSITE/UniProt

site_id	PS01303
Number of Residues	10
Details	BCCT BCCT family of transporters signature. GWTVfYWaWW

Chain	Residue	Details
A	GLY315-TRP324

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	333
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:20357772, ECO:0007744\|PDB:3HFX

Chain	Residue	Details
A	MET1-PRO12
B	PHE152-GLY186
B	CYS249-LYS253
B	ALA336-PHE349
B	MET432-LEU446
B	THR491-ASP504
C	MET1-PRO12
C	TRP68-SER90
C	PHE152-GLY186
C	CYS249-LYS253
C	ALA336-PHE349
A	TRP68-SER90
C	MET432-LEU446
C	THR491-ASP504
A	PHE152-GLY186
A	CYS249-LYS253
A	ALA336-PHE349
A	MET432-LEU446
A	THR491-ASP504
B	MET1-PRO12
B	TRP68-SER90

site_id	SWS_FT_FI2
Number of Residues	726
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:20357772, ECO:0007744\|PDB:3HFX

Chain	Residue	Details
A	LYS13-VAL30
A	SER404-ALA431
A	LEU447-LEU466
A	LEU469-VAL490
B	LYS13-VAL30
B	GLY52-PHE67
B	TRP91-SER98
B	GLU132-SER151
B	LEU187-MET219
B	LEU231-ALA248
B	ALA254-SER277
A	GLY52-PHE67
B	PHE312-LEU335
B	GLY350-LEU372
B	SER404-ALA431
B	LEU447-LEU466
B	LEU469-VAL490
C	LYS13-VAL30
C	GLY52-PHE67
C	TRP91-SER98
C	GLU132-SER151
C	LEU187-MET219
A	TRP91-SER98
C	LEU231-ALA248
C	ALA254-SER277
C	PHE312-LEU335
C	GLY350-LEU372
C	SER404-ALA431
C	LEU447-LEU466
C	LEU469-VAL490
A	GLU132-SER151
A	LEU187-MET219
A	LEU231-ALA248
A	ALA254-SER277
A	PHE312-LEU335
A	GLY350-LEU372

site_id	SWS_FT_FI3
Number of Residues	378
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:20357772, ECO:0007744\|PDB:3HFX

Chain	Residue	Details
A	ARG31-TRP51
B	GLY278-GLY311
B	LEU373-LEU403
B	GLY467-GLY468
C	ARG31-TRP51
C	CYS99-LYS131
C	GLN220-GLN230
C	GLY278-GLY311
C	LEU373-LEU403
C	GLY467-GLY468
A	CYS99-LYS131
A	GLN220-GLN230
A	GLY278-GLY311
A	LEU373-LEU403
A	GLY467-GLY468
B	ARG31-TRP51
B	CYS99-LYS131
B	GLN220-GLN230

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:20829798, ECO:0007744\|PDB:2WSX

Chain	Residue	Details
A	TYR114
C	GLY315
C	TRP323
C	MET331
A	GLY315
A	TRP323
A	MET331
B	TYR114
B	GLY315
B	TRP323
B	MET331
C	TYR114

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:20357772, ECO:0007744\|PDB:3HFX

Chain	Residue	Details
A	TRP142
A	TYR327
B	TRP142
B	TYR327
C	TRP142
C	TYR327

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)