2WSQ
MonoTIM mutant RMM0-1, dimeric form.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0020015 | cellular_component | glycosome |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0020015 | cellular_component | glycosome |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| C | 0004807 | molecular_function | triose-phosphate isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005777 | cellular_component | peroxisome |
| C | 0005829 | cellular_component | cytosol |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019563 | biological_process | glycerol catabolic process |
| C | 0020015 | cellular_component | glycosome |
| C | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| D | 0004807 | molecular_function | triose-phosphate isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005777 | cellular_component | peroxisome |
| D | 0005829 | cellular_component | cytosol |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019563 | biological_process | glycerol catabolic process |
| D | 0020015 | cellular_component | glycosome |
| D | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1251 |
| Chain | Residue |
| A | ILE172 |
| A | HOH2376 |
| A | GLY173 |
| A | SER213 |
| A | GLY234 |
| A | GLY235 |
| A | HOH2335 |
| A | HOH2336 |
| A | HOH2358 |
| A | HOH2375 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1251 |
| Chain | Residue |
| B | ALA171 |
| B | GLY173 |
| B | GLY212 |
| B | SER213 |
| B | GLY234 |
| B | GLY235 |
| B | HOH2324 |
| B | HOH2350 |
| B | HOH2352 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1251 |
| Chain | Residue |
| C | ALA171 |
| C | ILE172 |
| C | GLY173 |
| C | SER213 |
| C | GLY234 |
| C | GLY235 |
| C | HOH2328 |
| C | HOH2356 |
| C | HOH2370 |
| C | HOH2371 |
| C | HOH2372 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1251 |
| Chain | Residue |
| D | ALA171 |
| D | ILE172 |
| D | GLY173 |
| D | SER213 |
| D | GLY234 |
| D | GLY235 |
| D | HOH2334 |
| D | HOH2382 |
| D | HOH2428 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1252 |
| Chain | Residue |
| A | ARG226 |
| A | HOH2352 |
| C | GLY199 |
| C | ALA200 |
| C | ASP201 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1252 |
| Chain | Residue |
| B | LYS152 |
| D | LYS156 |
| D | GLY199 |
| D | ALA200 |
| D | ASP201 |
| D | VAL202 |
| D | HOH2430 |
| D | HOH2431 |
| D | HOH2432 |
| D | HOH2433 |
| D | HOH2434 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1252 |
| Chain | Residue |
| B | ALA160 |
| B | GLU205 |
| B | ARG207 |
| B | HOH2366 |
| B | HOH2367 |
| B | HOH2368 |
| B | HOH2369 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1253 |
| Chain | Residue |
| B | ARG98 |
| B | TYR102 |
| B | HOH2370 |
| C | ARG98 |
| C | TYR102 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
| Chain | Residue | Details |
| A | ALA165-GLY175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Electrophile |
| Chain | Residue | Details |
| A | HIS95 | |
| B | HIS95 | |
| C | HIS95 | |
| D | HIS95 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | GLU167 | |
| B | GLU167 | |
| C | GLU167 | |
| D | GLU167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASN11 | |
| A | LYS13 | |
| B | ASN11 | |
| B | LYS13 | |
| C | ASN11 | |
| C | LYS13 | |
| D | ASN11 | |
| D | LYS13 |
