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2WRM

Identification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE QQ3 A 1532
ChainResidue
AARG422
AHOH2625
AMET423
ATYR477
ALEU497
AARG498
AARG501
ATRP528
AHOH2587
AHOH2624

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE QQ3 A 1533
ChainResidue
ASER19
ATHR41
AARG43
ASER44
AARG154
AGLN436
AGLU437
AQQ31534
AHOH2080
AHOH2627

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE QQ3 A 1534
ChainResidue
AGLY152
AARG154
AQQ31533
AHOH2629

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues118
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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