2WR8

Structure of Pyrococcus horikoshii SAM hydroxide adenosyltransferase in complex with SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH A 1257

Chain	Residue
A	ASP7
A	TYR212
A	SER226
A	HIS227
A	GLU231
A	VAL234
A	ASN235
A	MET236
A	HOH2069
A	HOH2071
A	TYR14
A	HIS41
A	ASP68
A	THR125
A	PHE126
A	ASP179
A	PHE181
A	ASN183

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|Ref.3, ECO:0007744|PDB:1WU8

Chain	Residue	Details
A	ASP7
A	HIS41
A	ASP68
A	ASN183
A	VAL234

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:19739191, ECO:0007744|PDB:2WR8

Chain	Residue	Details
A	TYR212
A	SER226
A	GLU231
A	MET236

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Important for activity => ECO:0000305|PubMed:19739191

Chain	Residue	Details
A	ASP68
A	ARG75
A	HIS127

---