2WP2

Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
P	GLY14-HIS18

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site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SwpFqqpvDavklklpDYYtiIktpMdlntIkkrlenky..Yekaseciedfnt.MfsNCylY

Chain	Residue	Details
A	SER48-TYR107

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	DNA_BIND:

Chain	Residue	Details
P	LYS16-LYS20
Q	LYS16-LYS20
B	ASN108
B	ASP113

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16980586

Chain	Residue	Details
P	SER1
Q	SER1

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000269|PubMed:16699504

Chain	Residue	Details
P	ARG3
Q	ARG3

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	ALY5
Q	ALY5

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	ALY8
P	LYS16
Q	ALY8
Q	LYS16

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS12
Q	LYS12

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P62803

Chain	Residue	Details
P	LYS20
Q	LYS20

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site_id	SWS_FT_FI8
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
P	LYS12
P	LYS20
Q	LYS12
Q	LYS20

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