Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WOA

MMP12 complex with a beta hydroxy carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0031012	cellular_component	extracellular matrix
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0031012	cellular_component	extracellular matrix
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1268

Chain	Residue
A	ARG117
A	THR154
A	GLY155

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1268

Chain	Residue
B	ARG135
B	LYS136
B	GLN139

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1269

Chain	Residue
A	ARG135
A	LYS136
A	GLN139

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 023 B 1269

Chain	Residue
A	GLN259
A	SER260
B	GLY179
B	ILE180
B	LEU181
B	ALA182
B	LEU214
B	THR215
B	HIS218
B	GLU219
B	HIS222
B	HIS228
B	PRO238
B	THR239
B	TYR240
B	LYS241
B	ZN1270
D	SER207
D	GOL1272

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 023 D 1266

Chain	Residue
B	SER207
C	GLN259
C	SER260
D	GLY179
D	ILE180
D	LEU181
D	ALA182
D	LEU214
D	THR215
D	HIS218
D	GLU219
D	HIS222
D	HIS228
D	PRO238
D	THR239
D	TYR240
D	LYS241
D	ZN1267
D	GOL1271
D	HOH2085
D	HOH2102
D	HOH2103

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1270

Chain	Residue
A	HIS218
A	HIS222
A	HIS228
A	5761273

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1271

Chain	Residue
A	HIS168
A	ASP170
A	HIS183
A	HIS196

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1272

Chain	Residue
A	ASP175
A	GLY176
A	GLY178
A	ILE180
A	ASP198
A	GLU201

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1270

Chain	Residue
B	HIS218
B	HIS222
B	HIS228
B	0231269

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1271

Chain	Residue
B	HIS168
B	ASP170
B	HIS183
B	HIS196

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1272

Chain	Residue
B	ASP175
B	GLY176
B	GLY178
B	ILE180
B	ASP198
B	GLU201

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1273

Chain	Residue
B	ASP158
B	GLY190
B	GLY192
B	ASP194
B	HOH2047
B	HOH2073

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 1274

Chain	Residue
B	ASP124
B	GLU199
B	GLU201
B	HOH2088

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1268

Chain	Residue
C	HIS218
C	HIS222
C	HIS228
C	5761273

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1269

Chain	Residue
C	HIS168
C	ASP170
C	HIS183
C	HIS196

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1270

Chain	Residue
C	ILE180
C	ASP198
C	GLU201
C	ASP175
C	GLY176
C	GLY178

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1271

Chain	Residue
C	ASP158
C	GLY190
C	ILE191
C	GLY192
C	ASP194

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1272

Chain	Residue
C	ASP124
C	GLU199
C	GLU201
C	HOH2011
C	HOH2037

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1267

Chain	Residue
D	HIS218
D	HIS222
D	HIS228
D	0231266

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1268

Chain	Residue
D	HIS168
D	ASP170
D	HIS183
D	HIS196

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 1269

Chain	Residue
D	ASP175
D	GLY176
D	GLY178
D	ILE180
D	ASP198
D	GLU201

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 1270

Chain	Residue
D	ASP124
D	GLU199
D	GLU201
D	HOH2007
D	HOH2067

site_id	CC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 576 A 1273

Chain	Residue
A	LEU181
A	ALA182
A	LEU214
A	HIS218
A	GLU219
A	HIS222
A	HIS228
A	ALA234
A	VAL235
A	PHE237
A	THR239
A	TYR240
A	LYS241
A	ZN1270
A	HOH2103

site_id	CC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 576 C 1273

Chain	Residue
C	LEU181
C	ALA182
C	LEU214
C	HIS218
C	GLU219
C	HIS222
C	HIS228
C	VAL235
C	PHE237
C	PRO238
C	THR239
C	TYR240
C	LYS241
C	ZN1268

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 1271

Chain	Residue
B	SER207
B	GLY209
B	TYR240
B	TYR242
D	LEU181
D	THR210
D	TYR240
D	0231266
D	HOH2104

site_id	CC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 1272

Chain	Residue
B	LEU181
B	THR210
B	0231269
D	SER207
D	GLY208
D	GLY209
D	TYR240
D	TYR242
D	HOH2104
D	HOH2105

site_id	CC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 1274

Chain	Residue
A	ARG110
A	HOH2104
A	HOH2105
A	HOH2106
B	ALA167
B	HIS168
B	GLY169
B	ASP170
B	PHE171
B	HIS172
B	ALA173
B	HOH2055

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 D 1273

Chain	Residue
C	ARG110
D	ALA167
D	HIS168
D	GLY169
D	ASP170
D	PHE171
D	HIS172
D	HOH2047
D	HOH2106
D	HOH2107

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1274

Chain	Residue
C	THR204
C	THR205
C	HIS206
C	SER207
C	GLY208
C	HOH2082

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1275

Chain	Residue
A	ALA167
A	HIS168
A	GLY169
A	ASP170
A	PHE171
A	HOH2050

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL

Chain	Residue	Details
A	THR215-LEU224

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE:

Chain	Residue	Details
A	GLU219
B	GLU219
C	GLU219
D	GLU219

site_id	SWS_FT_FI2
Number of Residues	76
Details	BINDING:

Chain	Residue	Details
A	ASP124
A	GLY190
A	GLY192
A	ASP194
A	HIS196
A	ASP198
A	GLU199
A	GLU201
A	HIS218
A	HIS222
A	HIS228
A	ASP158
B	ASP124
B	ASP158
B	HIS168
B	ASP170
B	ASP175
B	GLY176
B	GLY178
B	ILE180
B	HIS183
B	GLY190
A	HIS168
B	GLY192
B	ASP194
B	HIS196
B	ASP198
B	GLU199
B	GLU201
B	HIS218
B	HIS222
B	HIS228
C	ASP124
A	ASP170
C	ASP158
C	HIS168
C	ASP170
C	ASP175
C	GLY176
C	GLY178
C	ILE180
C	HIS183
C	GLY190
C	GLY192
A	ASP175
C	ASP194
C	HIS196
C	ASP198
C	GLU199
C	GLU201
C	HIS218
C	HIS222
C	HIS228
D	ASP124
D	ASP158
A	GLY176
D	HIS168
D	ASP170
D	ASP175
D	GLY176
D	GLY178
D	ILE180
D	HIS183
D	GLY190
D	GLY192
D	ASP194
A	GLY178
D	HIS196
D	ASP198
D	GLU199
D	GLU201
D	HIS218
D	HIS222
D	HIS228
A	ILE180
A	HIS183

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	MET236
A	GLU219

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
B	MET236
B	GLU219

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
C	MET236
C	GLU219

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
D	MET236
D	GLU219

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	GLU219

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
B	GLU219

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
C	GLU219

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
D	GLU219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)