2WMC

Crystal structure of eukaryotic initiation factor 4E from Pisum sativum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation
B	0003723	molecular_function	RNA binding
B	0003743	molecular_function	translation initiation factor activity
B	0005737	cellular_component	cytoplasm
B	0006413	biological_process	translational initiation
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005737	cellular_component	cytoplasm
C	0006413	biological_process	translational initiation
D	0003723	molecular_function	RNA binding
D	0003743	molecular_function	translation initiation factor activity
D	0005737	cellular_component	cytoplasm
D	0006413	biological_process	translational initiation
E	0003723	molecular_function	RNA binding
E	0003743	molecular_function	translation initiation factor activity
E	0005737	cellular_component	cytoplasm
E	0006413	biological_process	translational initiation
F	0003723	molecular_function	RNA binding
F	0003743	molecular_function	translation initiation factor activity
F	0005737	cellular_component	cytoplasm
F	0006413	biological_process	translational initiation
G	0003723	molecular_function	RNA binding
G	0003743	molecular_function	translation initiation factor activity
G	0005737	cellular_component	cytoplasm
G	0006413	biological_process	translational initiation
H	0003723	molecular_function	RNA binding
H	0003743	molecular_function	translation initiation factor activity
H	0005737	cellular_component	cytoplasm
H	0006413	biological_process	translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MGP A 500

Chain	Residue
A	TRP75
A	TRP121
A	GLU122
A	ARG171
A	LYS176
A	ARG220
A	HOH2125

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MGP B 500

Chain	Residue
B	TRP121
B	GLU122
B	LYS176
B	HOH2110
B	TRP75
B	LYS120

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MGP C 500

Chain	Residue
C	TRP75
C	LYS120
C	TRP121
C	GLU122
C	ARG171
C	LYS176
C	HOH2094
C	HOH2095

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MGP D 500

Chain	Residue
D	TRP75
D	LYS120
D	TRP121
D	GLU122
D	ARG171
D	LYS176
D	HOH2122

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MGP E 500

Chain	Residue
E	TRP75
E	LYS120
E	TRP121
E	GLU122
E	ARG171
E	LYS176
E	HOH2093

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MGP F 500

Chain	Residue
A	LYS116
F	TRP75
F	TRP121
F	GLU122
F	ARG171
F	LYS176
F	HOH2066

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MGP G 500

Chain	Residue
G	TRP75
G	LYS120
G	TRP121
G	GLU122
G	ARG171
G	LYS176
G	HOH2088

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MGP H 500

Chain	Residue
H	LYS69
H	TRP75
H	LYS120
H	TRP121
H	GLU122
H	ARG171
H	LYS176
H	HOH2032

---

Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DFycFKhkIePkWEDpicanGGKW

Chain	Residue	Details
A	ASP109-TRP132

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:21283665, ECO:0007744|PDB:2WMC

Chain	Residue	Details
A	LYS71
C	TRP121
C	ARG171
C	ARG216
D	LYS71
D	TRP121
D	ARG171
D	ARG216
E	LYS71
E	TRP121
E	ARG171
A	TRP121
E	ARG216
F	LYS71
F	TRP121
F	ARG171
F	ARG216
G	LYS71
G	TRP121
G	ARG171
G	ARG216
H	LYS71
A	ARG171
H	TRP121
H	ARG171
H	ARG216
A	ARG216
B	LYS71
B	TRP121
B	ARG171
B	ARG216
C	LYS71

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P29557

Chain	Residue	Details
A	LYS103
B	LYS103
C	LYS103
D	LYS103
E	LYS103
F	LYS103
G	LYS103
H	LYS103

---