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2WKR

Structure of a photoactivatable Rac1 containing the Lov2 C450M Mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0001764biological_processneuron migration
A0001934biological_processpositive regulation of protein phosphorylation
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006954biological_processinflammatory response
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0008361biological_processregulation of cell size
A0009611biological_processresponse to wounding
A0009653biological_processanatomical structure morphogenesis
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0010595biological_processpositive regulation of endothelial cell migration
A0010764biological_processnegative regulation of fibroblast migration
A0010811biological_processpositive regulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030032biological_processlamellipodium assembly
A0030036biological_processactin cytoskeleton organization
A0030041biological_processactin filament polymerization
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030865biological_processcortical cytoskeleton organization
A0031116biological_processpositive regulation of microtubule polymerization
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031996molecular_functionthioesterase binding
A0032587cellular_componentruffle membrane
A0032707biological_processnegative regulation of interleukin-23 production
A0032956biological_processregulation of actin cytoskeleton organization
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043197cellular_componentdendritic spine
A0043652biological_processengulfment of apoptotic cell
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045428biological_processregulation of nitric oxide biosynthetic process
A0045730biological_processrespiratory burst
A0048012biological_processhepatocyte growth factor receptor signaling pathway
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048870biological_processcell motility
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051668biological_processlocalization within membrane
A0051894biological_processpositive regulation of focal adhesion assembly
A0055038cellular_componentrecycling endosome membrane
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060263biological_processregulation of respiratory burst
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071526biological_processsemaphorin-plexin signaling pathway
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0097178biological_processruffle assembly
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0101003cellular_componentficolin-1-rich granule membrane
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GTP A 1722
ChainResidue
AASP554
APRO577
ATHR578
AGLY603
ALYS659
AASP661
ALEU662
ASER701
AALA702
ALEU703
AMG1724
AGLY555
AHOH2085
AHOH2095
AHOH2128
AHOH2212
AHOH2213
AHOH2214
AALA556
AVAL557
AGLY558
ALYS559
ATHR560
ACYS561
ATYR575

site_idAC2
Number of Residues23
DetailsBINDING SITE FOR RESIDUE FMN A 1723
ChainResidue
AVAL416
ATHR418
AASN425
AASN449
AMET450
AARG451
ALEU453
AGLN454
AVAL463
AILE466
AARG467
AARG467
AILE470
AASN482
AASN492
APHE494
ALEU496
AGLY511
AGLN513
AHOH2028
AHOH2037
AHOH2039
AHOH2215

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1724
ChainResidue
ATHR560
ATHR578
AGTP1722
AHOH2128
AHOH2212

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1725
ChainResidue
ATHR704
AARG706

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1726
ChainResidue
ASER626
ALYS659

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
AALA556
AGLY573
AGLY603

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
ALYS659
AALA702

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR575

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR578

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
ASER614

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR575

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR578

site_idSWS_FT_FI8
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
ALYS690

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
ALYS709

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ALEU604

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA556

222624

PDB entries from 2024-07-17

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