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2WKQ

Structure of a photoactivatable Rac1 containing the Lov2 C450A Mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0001764biological_processneuron migration
A0001934biological_processpositive regulation of protein phosphorylation
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006954biological_processinflammatory response
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0008361biological_processregulation of cell size
A0009611biological_processresponse to wounding
A0009653biological_processanatomical structure morphogenesis
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0010595biological_processpositive regulation of endothelial cell migration
A0010764biological_processnegative regulation of fibroblast migration
A0010811biological_processpositive regulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030032biological_processlamellipodium assembly
A0030036biological_processactin cytoskeleton organization
A0030041biological_processactin filament polymerization
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030865biological_processcortical cytoskeleton organization
A0031116biological_processpositive regulation of microtubule polymerization
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031996molecular_functionthioesterase binding
A0032587cellular_componentruffle membrane
A0032707biological_processnegative regulation of interleukin-23 production
A0032956biological_processregulation of actin cytoskeleton organization
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043197cellular_componentdendritic spine
A0043652biological_processengulfment of apoptotic cell
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045428biological_processregulation of nitric oxide biosynthetic process
A0045730biological_processrespiratory burst
A0048012biological_processhepatocyte growth factor receptor signaling pathway
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048870biological_processcell motility
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051668biological_processlocalization within membrane
A0051894biological_processpositive regulation of focal adhesion assembly
A0055038cellular_componentrecycling endosome membrane
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060263biological_processregulation of respiratory burst
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071526biological_processsemaphorin-plexin signaling pathway
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0097178biological_processruffle assembly
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0101003cellular_componentficolin-1-rich granule membrane
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
Functional Information from PDB Data
site_idAC1
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GTP A 1722
ChainResidue
AGLY555
APRO577
ATHR578
AGLY603
ALYS659
AASP661
ALEU662
ASER701
AALA702
ALEU703
AMG1724
AALA556
AHOH2164
AHOH2225
AHOH2388
AHOH2389
AHOH2390
AHOH2391
AHOH2392
AVAL557
AGLY558
ALYS559
ATHR560
ACYS561
APHE571
ATYR575

site_idAC2
Number of Residues30
DetailsBINDING SITE FOR RESIDUE FMN A 1723
ChainResidue
AVAL416
ATHR418
AASN425
AASN449
AALA450
AARG451
ALEU453
AGLN454
AVAL463
AARG464
AILE466
AARG467
AARG467
AILE470
ALEU480
AASN482
AASN492
APHE494
ALEU496
APHE509
AILE510
AGLY511
AGLN513
ACL1726
AHOH2020
AHOH2050
AHOH2393
AHOH2394
AHOH2395
AHOH2396

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1724
ChainResidue
ATHR560
ATHR578
AGTP1722
AHOH2225
AHOH2391

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1725
ChainResidue
ASER626
ALYS659
AHOH2258

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1726
ChainResidue
AASN425
AASN449
AARG467
AILE470
AFMN1723

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1727
ChainResidue
ATHR704
AARG706
AHOH2280

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1728
ChainResidue
AGLY516
ATHR517
AGLU699
AHOH2107
AHOH2365
AHOH2397

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1729
ChainResidue
ATHR477
AGLN479
ALEU493
AGLU525
AHOH2120

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
AALA556
AGLY573
AGLY603

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
ALYS659
AALA702

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR575

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR578

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
ASER614

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR575

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR578

site_idSWS_FT_FI8
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
ALYS690

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
ALYS709

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ALEU604

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA556

219140

PDB entries from 2024-05-01

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