2WJY

Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 Orthorhombic form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS123
A	CYS126
A	CYS145
A	HIS155

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS137
A	SER140
A	HIS159
A	CYS165

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	CYS186
A	CYS209
A	CYS213
A	CYS183

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 990

Chain	Residue
A	PRO494
A	GLY495
A	ARG703
A	GLY831
A	ARG865
A	HOH2091
A	HOH2244
A	HOH2245
A	HOH2246
A	HOH2247

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 991

Chain	Residue
A	TYR764
A	ARG843
A	HIS847
A	GLN848
A	GLY849
A	HOH2206

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 992

Chain	Residue
A	ARG594
A	SER759

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 993

Chain	Residue
A	ARG832
A	HOH2248
A	HOH2250

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 994

Chain	Residue
A	ASN472
A	HIS473
A	GLN722
A	HOH2081

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 995

Chain	Residue
A	ARG462
A	PHE463
A	THR464
A	VAL476
A	HOH2252

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 996

Chain	Residue
A	THR794
A	PRO795
A	SER825
A	VAL826
A	GLY851
A	PHE852
A	HOH2253
A	HOH2254

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 997

Chain	Residue
A	LEU320
A	SER323

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Region: {"description":"C3H","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Region: {"description":"CC/SHH/C","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---