2WIT

CRYSTAL STRUCTURE OF THE SODIUM-COUPLED GLYCINE BETAINE SYMPORTER BETP FROM CORYNEBACTERIUM GLUTAMICUM WITH BOUND SUBSTRATE

Replaces:  2W8A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0015293	molecular_function	symporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0071705	biological_process	nitrogen compound transport
B	0005886	cellular_component	plasma membrane
B	0015293	molecular_function	symporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0071705	biological_process	nitrogen compound transport
C	0005886	cellular_component	plasma membrane
C	0015293	molecular_function	symporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0071705	biological_process	nitrogen compound transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BET A 1001

Chain	Residue
A	ALA148
A	TRP189
A	TRP194
A	TYR197
A	TRP374
A	TRP377

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BET B 1001

Chain	Residue
B	TYR197
B	TRP374
B	TRP377
B	ALA148
B	TRP189
B	TRP194

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BET C 1001

Chain	Residue
C	ALA148
C	GLY149
C	TRP189
C	TRP194
C	TRP374

---

Functional Information from PROSITE/UniProt

site_id	PS01303
Number of Residues	10
Details	BCCT BCCT family of transporters signature. SWTIfYWaWW

Chain	Residue	Details
A	SER365-TRP374

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	277
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24141878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	213
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	207
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19262666","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22940865","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25023443","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19262666","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22940865","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19262666","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22940865","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---