2WH5

Crystal structure of human acyl-CoA binding domain 4 complexed with stearoyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
B	0000062	molecular_function	fatty-acyl-CoA binding
C	0000062	molecular_function	fatty-acyl-CoA binding
D	0000062	molecular_function	fatty-acyl-CoA binding
E	0000062	molecular_function	fatty-acyl-CoA binding
F	0000062	molecular_function	fatty-acyl-CoA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE STE A 801

Chain	Residue
A	ILE19
A	PRO30
A	TYR32
A	ST9901

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ST9 A 901

Chain	Residue
A	LYS24
A	GLY26
A	SER27
A	TYR28
A	PRO30
A	PHE38
A	TYR39
A	TYR42
A	LYS43
A	LYS65
A	TYR84
A	STE801
A	HOH2001
A	VAL16
A	ILE19
A	GLN20
A	LEU22
A	PRO23

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE STE B 801

Chain	Residue
B	PHE38
B	TYR64
B	ST9901

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ST9 B 901

Chain	Residue
B	VAL16
B	ILE19
B	GLN20
B	LEU22
B	PRO23
B	SER27
B	TYR28
B	PRO30
B	PHE38
B	TYR39
B	TYR42
B	LYS43
B	LYS65
B	TYR84
B	VAL91
B	STE801

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE STE C 801

Chain	Residue
C	LEU22
C	MET35
C	PHE38
C	TYR64
C	ST9901

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ST9 C 901

Chain	Residue
C	VAL16
C	ILE19
C	GLN20
C	PRO23
C	LYS24
C	ASN25
C	GLY26
C	SER27
C	TYR28
C	PRO30
C	PHE38
C	TYR39
C	TYR42
C	LYS43
C	LYS65
C	TYR84
C	STE801

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE STE D 801

Chain	Residue
D	ILE19
D	LEU22
D	PHE38
D	VAL91
D	ST9901

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ST9 D 901

Chain	Residue
D	VAL16
D	ILE19
D	GLN20
D	LEU22
D	PRO23
D	LYS24
D	GLY26
D	SER27
D	TYR28
D	PHE38
D	TYR39
D	TYR42
D	LYS43
D	LYS65
D	TYR84
D	STE801

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE STE E 801

Chain	Residue
E	PHE38
E	TYR64
E	LYS65
E	ST9901

---

site_id	BC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ST9 E 901

Chain	Residue
E	LYS65
E	TYR84
E	MET88
E	VAL91
E	ILE96
E	STE801
F	GLN11
F	ALA15
F	ILE85
F	MET88
F	LYS89
F	ST9901
E	VAL16
E	ILE19
E	GLN20
E	PRO23
E	SER27
E	TYR28
E	PRO30
E	PHE38
E	TYR39
E	TYR42
E	LYS43

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE STE F 801

Chain	Residue
F	PRO30
F	TYR32
F	MET35
F	LEU36
F	PHE38
F	LYS65
F	ST9901

---

site_id	BC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ST9 F 901

Chain	Residue
E	MET88
E	LYS89
E	ALA92
E	ST9901
F	VAL16
F	ILE19
F	GLN20
F	PRO23
F	LYS24
F	GLY26
F	SER27
F	TYR28
F	PHE38
F	TYR39
F	TYR42
F	LYS43
F	LYS65
F	TYR84
F	STE801

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE COA D 1099

Chain	Residue
B	LYS74
B	HOH2023
D	ARG54
D	HOH2006
D	HOH2011
F	ARG54
F	ARG63
F	TYR64

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE COA E 1099

Chain	Residue
A	ARG54
A	ARG63
A	TYR64
B	ARG63
B	TYR64
C	LYS74
E	ARG54
E	ARG63

---

Functional Information from PROSITE/UniProt

site_id	PS00880
Number of Residues	19
Details	ACB_1 Acyl-CoA-binding (ACB) domain signature. PSyEeMlrFYSyYKQATmG

Chain	Residue	Details
A	PRO30-GLY48

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	ILE19
C	TYR39
C	LYS65
C	TYR84
D	ILE19
D	TYR39
D	LYS65
D	TYR84
E	ILE19
E	TYR39
E	LYS65
A	TYR39
E	TYR84
F	ILE19
F	TYR39
F	LYS65
F	TYR84
A	LYS65
A	TYR84
B	ILE19
B	TYR39
B	LYS65
B	TYR84
C	ILE19

---