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2WGP

Crystal structure of human dual specificity phosphatase 14

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0004726molecular_functionnon-membrane spanning protein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0006470biological_processprotein dephosphorylation
A0016311biological_processdephosphorylation
A0017017molecular_functionMAP kinase tyrosine/serine/threonine phosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0030946molecular_functionprotein tyrosine phosphatase activity, metal-dependent
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0140791molecular_functionhistone H2AXS140 phosphatase activity
A0140793molecular_functionhistone H2AXY142 phosphatase activity
A0180004molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
A0180005molecular_functionRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
A0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
A0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
A1990439molecular_functionMAP kinase serine/threonine phosphatase activity
B0003723molecular_functionRNA binding
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0004726molecular_functionnon-membrane spanning protein tyrosine phosphatase activity
B0005515molecular_functionprotein binding
B0006338biological_processchromatin remodeling
B0006357biological_processregulation of transcription by RNA polymerase II
B0006470biological_processprotein dephosphorylation
B0016311biological_processdephosphorylation
B0017017molecular_functionMAP kinase tyrosine/serine/threonine phosphatase activity
B0017018molecular_functionmyosin phosphatase activity
B0030946molecular_functionprotein tyrosine phosphatase activity, metal-dependent
B0033192molecular_functioncalmodulin-dependent protein phosphatase activity
B0140791molecular_functionhistone H2AXS140 phosphatase activity
B0140793molecular_functionhistone H2AXY142 phosphatase activity
B0180004molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
B0180005molecular_functionRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
B0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
B0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
B1990439molecular_functionMAP kinase serine/threonine phosphatase activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 A 200
ChainResidue
AILE61
AHOH2179
AASP80
ACYS111
AALA112
AALA113
AGLY114
AVAL115
ASER116
AARG117

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 B 200
ChainResidue
BILE61
BASP80
BCYS111
BALA112
BALA113
BGLY114
BVAL115
BSER116
BARG117

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCaaGvsRSA
ChainResidueDetails
AVAL109-ALA119

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000269|PubMed:19770498
ChainResidueDetails
ACYS111
BCYS111

227111

PDB entries from 2024-11-06

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