Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WAT

Structure of the fungal type I FAS PPT domain in complex with CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0000287	molecular_function	magnesium ion binding
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0000287	molecular_function	magnesium ion binding
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0000287	molecular_function	magnesium ion binding
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
E	0000287	molecular_function	magnesium ion binding
E	0006633	biological_process	fatty acid biosynthetic process
E	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0000287	molecular_function	magnesium ion binding
F	0006633	biological_process	fatty acid biosynthetic process
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE COA C 2887

Chain	Residue
A	TYR1798
A	HIS1873
A	HOH2034
A	HOH2077
C	ASP1772
C	GLU1774
C	GLU1817
C	PHE1820
C	LYS1821
C	VAL1825
C	SER1827
A	SER1808
C	LEU1828
C	GLY1829
C	ALA1832
C	ALA1833
C	LEU1834
C	HOH2041
C	HOH2084
C	HOH2085
C	HOH2086
C	HOH2087
A	ARG1841
C	MG2888
A	LYS1844
A	ASN1845
A	ALA1846
A	PRO1847
A	ILE1871
A	SER1872

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE COA B 2887

Chain	Residue
A	ASP1772
A	GLU1817
A	LYS1821
A	VAL1825
B	TYR1798
B	SER1808
B	PHE1820
B	VAL1825
B	LYS1826
B	LEU1828
B	ARG1841
B	ASN1845
B	ALA1846
B	PRO1847
B	ALA1855
B	ILE1871
B	SER1872
B	HIS1873
B	HOH2096
B	HOH2104
B	HOH2105
B	HOH2106
B	HOH2108
B	COA2888
B	MG2890

site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE COA B 2888

Chain	Residue
B	ASP1772
B	GLU1817
B	PHE1820
B	LYS1821
B	VAL1825
B	SER1827
B	LEU1828
B	ALA1832
B	ALA1833
B	LEU1834
B	HOH2005
B	HOH2047
B	HOH2109
B	HOH2110
B	HOH2111
B	HOH2112
B	HOH2113
B	COA2887
B	MG2889
C	TYR1798
C	ARG1841
C	ASN1845
C	ALA1846
C	PRO1847
C	ILE1871
C	SER1872
C	HIS1873
C	HOH2027
C	HOH2076

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE COA E 2887

Chain	Residue
E	ASN1845
E	ALA1846
E	PRO1847
E	ILE1871
E	SER1872
E	HIS1873
E	HOH2064
E	HOH2072
E	HOH2074
E	HOH2075
E	HOH2076
E	HOH2077
D	ASP1772
D	GLU1817
D	LYS1821
D	VAL1825
D	SER1827
D	LEU1828
D	GLY1829
D	ALA1832
D	ALA1833
D	LEU1834
D	HOH2048
D	MG2887
E	TYR1798
E	ARG1841
E	LYS1844

site_id	AC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE COA E 2888

Chain	Residue
E	ASP1772
E	GLU1774
E	GLU1817
E	LYS1821
E	VAL1825
E	SER1827
E	LEU1828
E	GLY1829
E	ALA1833
E	LEU1834
E	HOH2029
E	HOH2032
E	HOH2078
E	HOH2079
E	HOH2080
E	MG2889
F	TYR1798
F	SER1808
F	ARG1841
F	ASN1845
F	ALA1846
F	PRO1847
F	ILE1871
F	SER1872
F	HIS1873
F	HOH2023

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 2887

Chain	Residue
D	ASP1772
D	VAL1773
D	GLU1774
E	SER1872
E	HIS1873
E	COA2887

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 2889

Chain	Residue
B	VAL1773
B	GLU1774
B	HOH2038
B	COA2888
C	HIS1873

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2890

Chain	Residue
A	VAL1773
A	GLU1774
B	HIS1873
B	COA2887

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 2888

Chain	Residue
A	SER1872
A	HIS1873
C	ASP1772
C	VAL1773
C	GLU1774
C	COA2887

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 2889

Chain	Residue
E	VAL1773
E	GLU1774
E	COA2888
F	HIS1873

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 2891

Chain	Residue
B	GLY1853
B	HOH2080
B	HOH2081

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 2889

Chain	Residue
D	GLY1853
D	GLY1853

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	122
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19679086","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1f7l

Chain	Residue	Details
A	HIS1873
A	LYS1821

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1f7l

Chain	Residue	Details
B	HIS1873
B	LYS1821

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1f7l

Chain	Residue	Details
C	HIS1873
C	LYS1821

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1f7l

Chain	Residue	Details
D	HIS1873
D	LYS1821

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1f7l

Chain	Residue	Details
E	HIS1873
E	LYS1821

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1f7l

Chain	Residue	Details
F	HIS1873
F	LYS1821

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)