2WA7

Structure of the M202V mutant of human filamin b actin binding domain at 1.85 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0030036	biological_process	actin cytoskeleton organization
A	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CAC A 1241

Chain	Residue
A	TRP148
A	LYS152
A	CYS178
A	PHE237
A	CO31244

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO3 A 1242

Chain	Residue
A	ASP43
A	ARG49
A	HOH2204

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO3 A 1243

Chain	Residue
A	ASN197
A	GLU200
A	TRP189

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO3 A 1244

Chain	Residue
A	GLU129
A	ASP130
A	TRP148
A	PRO238
A	CAC1241

---

Functional Information from PROSITE/UniProt

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QQnTFTRWCN

Chain	Residue	Details
A	GLN18-ASN27

---

site_id	PS00020
Number of Residues	25
Details	ACTININ_2 Actinin-type actin-binding domain signature 2. LvSIDSkAIvDgnlkLiLGLVWtLI

Chain	Residue	Details
A	LEU94-ILE118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Calponin-homology (CH) 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---