2W8R
The crystal structure of human SSADH in complex with NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004777 | molecular_function | succinate-semialdehyde dehydrogenase (NAD+) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006105 | biological_process | succinate metabolic process |
| A | 0006536 | biological_process | glutamate metabolic process |
| A | 0007417 | biological_process | central nervous system development |
| A | 0009013 | molecular_function | succinate-semialdehyde dehydrogenase [NAD(P)+] activity |
| A | 0009448 | biological_process | gamma-aminobutyric acid metabolic process |
| A | 0009450 | biological_process | gamma-aminobutyric acid catabolic process |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045202 | cellular_component | synapse |
| A | 0051932 | biological_process | synaptic transmission, GABAergic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADP A 702 |
| Chain | Residue |
| A | THR202 |
| A | THR288 |
| A | TRP204 |
| A | LYS228 |
| A | ALA230 |
| A | GLU231 |
| A | ALA264 |
| A | GLY268 |
| A | PHE282 |
| A | SER285 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | LEU368 |
| A | ARG369 |
| A | VAL370 |
| A | HIS413 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | GLN349 |
| A | ASP450 |
| A | THR451 |
| A | GLU452 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | LEU51 |
| A | ARG68 |
| A | SER83 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | ARG350 |
| A | LYS448 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | HOH2048 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | TYR159 |
| A | PHE206 |
| A | ARG334 |
| A | SER498 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
| Chain | Residue |
| A | VAL95 |
| A | ARG96 |
| A | ARG261 |
| A | LYS262 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
| Chain | Residue |
| A | VAL65 |
| A | LEU70 |
| A | GLY84 |
| A | LYS417 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1009 |
| Chain | Residue |
| A | ARG60 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1010 |
| Chain | Residue |
| A | TYR159 |
| A | ARG213 |
| A | ARG334 |
| A | VAL341 |
| A | SER498 |
| A | PHE504 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1101 |
| Chain | Residue |
| A | THR408 |
| A | GLY409 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1102 |
| Chain | Residue |
| A | ARG103 |
| A | ASN385 |
| A | GLU386 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. MELGGLAP |
| Chain | Residue | Details |
| A | MET305-PRO312 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007 |
| Chain | Residue | Details |
| A | GLU306 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10008 |
| Chain | Residue | Details |
| A | ALA340 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P20000 |
| Chain | Residue | Details |
| A | GLU306 | |
| A | GLU438 | |
| A | THR202 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19300440, ECO:0007744|PDB:2W8Q |
| Chain | Residue | Details |
| A | ARG334 | |
| A | SER498 | |
| A | ARG213 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19300440, ECO:0007744|PDB:2W8R |
| Chain | Residue | Details |
| A | LYS228 | |
| A | GLY284 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P20000 |
| Chain | Residue | Details |
| A | ASN205 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8BWF0 |
| Chain | Residue | Details |
| A | LYS265 | |
| A | LYS126 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BWF0 |
| Chain | Residue | Details |
| A | LYS402 | |
| A | LYS135 | |
| A | LYS184 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BWF0 |
| Chain | Residue | Details |
| A | LYS365 | |
| A | LYS411 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER499 |
