2W7F
Crystal structure of Y51FbsSHMT L-Ser external aldimine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006565 | biological_process | L-serine catabolic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0019264 | biological_process | glycine biosynthetic process from serine |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
A | 0046653 | biological_process | tetrahydrofolate metabolic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050897 | molecular_function | cobalt ion binding |
A | 0070905 | molecular_function | serine binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SER A 601 |
Chain | Residue |
A | SER31 |
A | PHE51 |
A | GLU53 |
A | TYR61 |
A | HIS122 |
A | HIS200 |
A | ARG357 |
A | PLP501 |
A | HOH2088 |
site_id | AC2 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE PLP A 501 |
Chain | Residue |
A | PHE51 |
A | GLU53 |
A | SER93 |
A | GLY94 |
A | ALA95 |
A | HIS122 |
A | ALA171 |
A | SER172 |
A | ASP197 |
A | ALA199 |
A | HIS200 |
A | THR223 |
A | HIS225 |
A | LYS226 |
A | GLY257 |
A | SER601 |
A | HOH2088 |
A | HOH2288 |
A | HOH2426 |
A | HOH2427 |
A | HOH2428 |
A | HOH2429 |
A | HOH2430 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE MPD A 720 |
Chain | Residue |
A | TYR152 |
A | ARG156 |
A | ILE186 |
A | LEU322 |
A | VAL387 |
A | HOH2239 |
A | HOH2242 |
A | HOH2347 |
A | HOH2431 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MPD A 721 |
Chain | Residue |
A | MET99 |
A | PHE131 |
A | TYR136 |
A | TYR136 |
A | HOH2432 |
A | HOH2432 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 801 |
Chain | Residue |
A | GLU371 |
A | GLU375 |
A | HOH2433 |
A | HOH2434 |
A | HOH2435 |
Functional Information from PROSITE/UniProt
site_id | PS00096 |
Number of Residues | 17 |
Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HFvTTTTHKTLrGPRGG |
Chain | Residue | Details |
A | HIS218-GLY234 |