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2W5A

Human Nek2 kinase ADP-bound

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP A 1280
ChainResidue
AGLY17
AARG164
AMG1281
AHOH2034
AHOH2158
AHOH2159
AHOH2205
AHOH2207
AHOH2342
AHOH2343
AHOH2344
ASER18
AHOH2345
AHOH2346
AHOH2347
AHOH2348
ACYS22
ALYS37
AGLU87
ATYR88
ACYS89
AASP93
APHE148

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 1281
ChainResidue
ALYS37
AARG164
AADP1280
AHOH2207
AHOH2220
AHOH2221
AHOH2347

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1282
ChainResidue
ALEU11
ALYS152
AGLN153
AHOH2337
AHOH2349
AHOH2350

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1283
ChainResidue
AHIS139
AARG140
AASP159
AHOH2110
AHOH2351
AHOH2352

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 1284
ChainResidue
ALEU122
AARG235
AASP242
AHIS276
AHIS277
AHOH2109
AHOH2278
AHOH2353

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1285
ChainResidue
AGLU246
AILE247
AGLU264
AASN268

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNVFL
ChainResidueDetails
AVAL137-LEU149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP141

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE14

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING:
ChainResidueDetails
ALYS37

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:17197699
ChainResidueDetails
ATHR170

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000305|PubMed:17197699, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER171

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17197699
ChainResidueDetails
ATHR175
ATHR179

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER184

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:17197699
ChainResidueDetails
ASER241

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PDB entries from 2024-06-12

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