2W51

Human mesencephalic astrocyte-derived neurotrophic factor (MANF)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005829	cellular_component	cytosol
A	0006986	biological_process	response to unfolded protein
A	0008083	molecular_function	growth factor activity
A	0008289	molecular_function	lipid binding
A	0031175	biological_process	neuron projection development
A	0033018	cellular_component	sarcoplasmic reticulum lumen
A	0036500	biological_process	ATF6-mediated unfolded protein response
A	0071542	biological_process	dopaminergic neuron differentiation
A	0120146	molecular_function	sulfatide binding
A	1905897	biological_process	regulation of response to endoplasmic reticulum stress

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	62
Details	Region: {"description":"Interacts with ERN1, EIF2AK3 and ATF6","evidences":[{"source":"PubMed","id":"36739529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9CXI5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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