2W41
Crystal structure of Plasmodium falciparum glycerol kinase with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004370 | molecular_function | glycerol kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006071 | biological_process | glycerol metabolic process |
| A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| A | 0006641 | biological_process | triglyceride metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0046167 | biological_process | glycerol-3-phosphate biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004370 | molecular_function | glycerol kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006071 | biological_process | glycerol metabolic process |
| B | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| B | 0006641 | biological_process | triglyceride metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0046167 | biological_process | glycerol-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP B1502 |
| Chain | Residue |
| B | GLY267 |
| B | MET415 |
| B | ASN418 |
| B | THR268 |
| B | GLY313 |
| B | VAL316 |
| B | PRO328 |
| B | ALA331 |
| B | SER332 |
| B | GLY413 |
| B | GLY414 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP A1502 |
| Chain | Residue |
| A | GLY267 |
| A | THR268 |
| A | GLY313 |
| A | VAL316 |
| A | PRO328 |
| A | ALA331 |
| A | SER332 |
| A | GLY413 |
| A | GLY414 |
| A | MET415 |
| A | ASN418 |
| A | HOH2145 |
| A | HOH2146 |
| A | HOH2147 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A1503 |
| Chain | Residue |
| A | ILE309 |
| A | THR311 |
| A | ALA312 |
| A | PHE350 |
| A | SER351 |
| A | GLY352 |
| A | HOH2088 |
| A | HOH2148 |
| B | PHE371 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B1503 |
| Chain | Residue |
| B | SER10 |
| B | THR11 |
| B | GLN12 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B1504 |
| Chain | Residue |
| A | PHE371 |
| B | ILE309 |
| B | THR311 |
| B | ALA312 |
| B | PHE350 |
| B | SER351 |
| B | GLY352 |
| B | HOH2152 |
| B | HOH2153 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B1505 |
| Chain | Residue |
| B | VAL72 |
| B | ILE73 |
| B | ILE74 |
| B | ASP234 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B1506 |
| Chain | Residue |
| B | TYR293 |
| B | LYS294 |
| B | PHE295 |
| B | ASP299 |
| B | LYS300 |
| B | LYS302 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A1504 |
| Chain | Residue |
| A | ARG83 |
| A | GLU84 |
| A | ASP246 |
| A | EDO1508 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A1505 |
| Chain | Residue |
| A | ASP123 |
| A | LYS127 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A1506 |
| Chain | Residue |
| A | ILE62 |
| A | LYS66 |
| A | VAL72 |
| A | ILE73 |
| A | ILE74 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A1507 |
| Chain | Residue |
| A | VAL182 |
| A | LEU196 |
| A | ILE217 |
| A | LYS218 |
| A | LYS294 |
| A | ASP297 |
| A | HOH2056 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B1507 |
| Chain | Residue |
| B | TYR367 |
| B | ARG496 |
| B | HOH2145 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A1508 |
| Chain | Residue |
| A | GLU84 |
| A | EDO1504 |
| A | EDO1509 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B1508 |
| Chain | Residue |
| B | GLU84 |
| B | TYR135 |
| B | EDO1509 |
| B | EDO1513 |
| B | HOH2154 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B1509 |
| Chain | Residue |
| B | GLN82 |
| B | ARG83 |
| B | GLU84 |
| B | ASP246 |
| B | EDO1508 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B1510 |
| Chain | Residue |
| B | GLU259 |
| B | GLY277 |
| B | GLU278 |
| B | HOH2083 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B1511 |
| Chain | Residue |
| B | ASN491 |
| B | HOH2155 |
| B | PHE388 |
| B | ASN391 |
| B | GLU392 |
| B | THR487 |
| B | TRP490 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A1509 |
| Chain | Residue |
| A | TYR135 |
| A | EDO1508 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A1510 |
| Chain | Residue |
| A | GLN197 |
| A | TRP198 |
| A | ILE217 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A1511 |
| Chain | Residue |
| A | ASP479 |
| A | LYS481 |
| B | ASP479 |
| B | ASP480 |
| B | LYS481 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B1512 |
| Chain | Residue |
| B | GLN197 |
| B | TRP198 |
| B | GLU216 |
| B | ILE217 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A1512 |
| Chain | Residue |
| A | SER10 |
| A | THR11 |
| A | ASP246 |
| A | HOH2152 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B1513 |
| Chain | Residue |
| B | EDO1508 |
Functional Information from PROSITE/UniProt
| site_id | PS00445 |
| Number of Residues | 21 |
| Details | FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. AsIYGMtfnters.HIVRALLE |
| Chain | Residue | Details |
| A | ALA364-GLU384 |
| site_id | PS00933 |
| Number of Residues | 13 |
| Details | FGGY_KINASES_1 FGGY family of carbohydrate kinases signature 1. YfSafKILWLIQN |
| Chain | Residue | Details |
| A | TYR135-ASN147 |
