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2W3Q

Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

Functional Information from GO Data
ChainGOidnamespacecontents
A0004089molecular_functioncarbonate dehydratase activity
A0008270molecular_functionzinc ion binding
A0016829molecular_functionlyase activity
A0034599biological_processcellular response to oxidative stress
A0046872molecular_functionmetal ion binding
A0071244biological_processcellular response to carbon dioxide
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1231
ChainResidue
ACYS68
AHIS124
ACYS127
AHOH2165

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A1232
ChainResidue
AVAL185
AGLN226
AHOH2131
AHOH2134

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1i6p
ChainResidueDetails
AARG72
AASP70

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PDB entries from 2024-10-30

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