2W1A
Non-covalent complex between dahp synthase and chorismate mutase from Mycobacterium tuberculosis with bound tsa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
| C | 0046417 | biological_process | chorismate metabolic process |
| D | 0046417 | biological_process | chorismate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 1463 |
| Chain | Residue |
| A | CYS87 |
| A | HIS369 |
| A | GLU411 |
| A | ASP441 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1464 |
| Chain | Residue |
| A | GLY282 |
| A | GLU283 |
| A | LYS306 |
| A | ARG337 |
| A | HOH2075 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CE1 A 1465 |
| Chain | Residue |
| A | PHE91 |
| A | MET92 |
| A | ASN94 |
| A | THR95 |
| A | ARG171 |
| A | ALA174 |
| A | ASN175 |
| B | ILE7 |
| B | SER54 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1466 |
| Chain | Residue |
| A | THR90 |
| A | PHE91 |
| A | MET92 |
| A | TYR147 |
| A | ASP150 |
| A | GLY154 |
| A | PHE155 |
| A | ARG168 |
| A | ARG171 |
| B | PRO8 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1467 |
| Chain | Residue |
| A | ASP138 |
| A | ARG145 |
| A | ARG148 |
| A | HOH2045 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1463 |
| Chain | Residue |
| B | GLY282 |
| B | GLU283 |
| B | LYS306 |
| B | ARG337 |
| B | HOH2103 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1464 |
| Chain | Residue |
| B | ARG23 |
| B | ARG256 |
| B | HOH2016 |
| B | HOH2062 |
| B | HOH2105 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 1465 |
| Chain | Residue |
| B | CYS87 |
| B | HIS369 |
| B | GLU411 |
| B | ASP441 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1466 |
| Chain | Residue |
| B | ARG135 |
| B | SER136 |
| B | ALA137 |
| B | ARG284 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1467 |
| Chain | Residue |
| B | PRO17 |
| B | LEU18 |
| B | ARG23 |
| B | LEU144 |
| B | ASP158 |
| B | ALA159 |
| B | HOH2038 |
| site_id | BC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TSA C 1091 |
| Chain | Residue |
| C | ARG18 |
| C | ARG35 |
| C | SER39 |
| C | ILE42 |
| C | ARG46 |
| C | LEU54 |
| C | VAL55 |
| C | ARG58 |
| C | GLU59 |
| C | LEU81 |
| C | ARG85 |
| C | HOH2001 |
| C | HOH2006 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TSA D 1091 |
| Chain | Residue |
| D | ARG18 |
| D | ARG35 |
| D | SER39 |
| D | ILE42 |
| D | ARG46 |
| D | LEU54 |
| D | VAL55 |
| D | ARG58 |
| D | GLU59 |
| D | LEU81 |
| D | ARG85 |
| D | HOH2008 |
| D | HOH2009 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19556970, ECO:0007744|PDB:2VKL |
| Chain | Residue | Details |
| C | ARG46 | |
| B | ARG126 | |
| B | GLU283 | |
| B | LYS306 | |
| B | ARG337 | |
| B | HIS369 | |
| B | GLU411 | |
| B | ASP441 | |
| C | VAL55 | |
| C | GLU59 | |
| D | ARG46 | |
| D | VAL55 | |
| D | GLU59 | |
| A | GLU411 | |
| A | ASP441 | |
| B | CYS87 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Important for catalysis => ECO:0000269|PubMed:19556970 |
| Chain | Residue | Details |
| C | ARG46 | |
| D | ARG46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | SITE: Important for activation via AroG => ECO:0000269|PubMed:19556970 |
| Chain | Residue | Details |
| C | GLY86 | |
| C | ARG87 | |
| C | LEU88 | |
| D | GLY86 | |
| D | ARG87 | |
| D | LEU88 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| C | ARG35 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| D | ARG35 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| C | ARG18 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| D | ARG18 |
