2W19
Non-covalent complex between dahp synthase and chorismate mutase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
| C | 0004106 | molecular_function | chorismate mutase activity |
| C | 0046417 | biological_process | chorismate metabolic process |
| D | 0004106 | molecular_function | chorismate mutase activity |
| D | 0046417 | biological_process | chorismate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1462 |
| Chain | Residue |
| A | THR114 |
| A | PRO120 |
| A | VAL121 |
| A | LYS123 |
| A | GLN239 |
| A | HOH2155 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1463 |
| Chain | Residue |
| A | LYS123 |
| A | GLU242 |
| A | HOH2037 |
| A | GLN70 |
| A | VAL121 |
| A | VAL122 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1464 |
| Chain | Residue |
| A | MET180 |
| A | THR187 |
| A | ILE243 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1465 |
| Chain | Residue |
| A | ARG135 |
| A | SER136 |
| A | ALA137 |
| A | ARG284 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1466 |
| Chain | Residue |
| A | VAL60 |
| A | PRO61 |
| A | SER62 |
| A | HOH2156 |
| B | ARG100 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1467 |
| Chain | Residue |
| A | GLY282 |
| A | GLU283 |
| A | LYS306 |
| A | ARG337 |
| A | HIS369 |
| A | HOH2157 |
| A | HOH2158 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1462 |
| Chain | Residue |
| B | ARG23 |
| B | GLU53 |
| B | ARG256 |
| B | HOH2032 |
| B | HOH2116 |
| B | HOH2179 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1463 |
| Chain | Residue |
| B | GLY282 |
| B | GLU283 |
| B | LYS306 |
| B | ARG337 |
| B | HIS369 |
| B | HOH2126 |
| B | HOH2180 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1464 |
| Chain | Residue |
| B | THR114 |
| B | PRO120 |
| B | VAL121 |
| B | LYS123 |
| B | ALA230 |
| B | HOH2181 |
| B | HOH2182 |
| B | HOH2183 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1465 |
| Chain | Residue |
| B | GLN70 |
| B | VAL121 |
| B | GLU242 |
| B | HOH2109 |
| B | HOH2184 |
| B | HOH2185 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1466 |
| Chain | Residue |
| B | ARG184 |
| B | THR187 |
| B | ALA241 |
| B | ILE243 |
| B | HOH2186 |
| B | HOH2187 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1467 |
| Chain | Residue |
| A | THR24 |
| A | HOH2010 |
| A | HOH2013 |
| B | ARG25 |
| B | VAL298 |
| B | HOH2188 |
| B | HOH2189 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1468 |
| Chain | Residue |
| B | ARG135 |
| B | SER136 |
| B | ALA137 |
| B | ARG284 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1469 |
| Chain | Residue |
| B | PRO17 |
| B | LEU18 |
| B | ARG23 |
| B | LEU144 |
| B | ALA159 |
| B | HOH2077 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19556970, ECO:0007744|PDB:2VKL |
| Chain | Residue | Details |
| C | ARG46 | |
| B | ARG126 | |
| B | GLU283 | |
| B | LYS306 | |
| B | ARG337 | |
| B | HIS369 | |
| B | GLU411 | |
| B | ASP441 | |
| C | VAL55 | |
| C | GLU59 | |
| D | ARG46 | |
| D | VAL55 | |
| D | GLU59 | |
| A | GLU411 | |
| A | ASP441 | |
| B | CYS87 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Important for catalysis => ECO:0000269|PubMed:19556970 |
| Chain | Residue | Details |
| C | ARG46 | |
| D | ARG46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | SITE: Important for activation via AroG => ECO:0000269|PubMed:19556970 |
| Chain | Residue | Details |
| C | GLY86 | |
| C | ARG87 | |
| C | LEU88 | |
| D | GLY86 | |
| D | ARG87 | |
| D | LEU88 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| C | ARG35 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| D | ARG35 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| D | ARG18 |
