2VWB

Structure of the archaeal Kae1-Bud32 fusion protein MJ1130: a model for the eukaryotic EKC-KEOPS subcomplex involved in transcription and telomere homeostasis.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000408	cellular_component	EKC/KEOPS complex
A	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
A	0003824	molecular_function	catalytic activity
A	0004222	molecular_function	metalloendopeptidase activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005506	molecular_function	iron ion binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006400	biological_process	tRNA modification
A	0006468	biological_process	protein phosphorylation
A	0008033	biological_process	tRNA processing
A	0008270	molecular_function	zinc ion binding
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0046872	molecular_function	metal ion binding
A	0061711	molecular_function	tRNA N(6)-L-threonylcarbamoyladenine synthase activity
A	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
A	0106310	molecular_function	protein serine kinase activity
B	0000166	molecular_function	nucleotide binding
B	0000408	cellular_component	EKC/KEOPS complex
B	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
B	0003824	molecular_function	catalytic activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0005506	molecular_function	iron ion binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006400	biological_process	tRNA modification
B	0006468	biological_process	protein phosphorylation
B	0008033	biological_process	tRNA processing
B	0008270	molecular_function	zinc ion binding
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0046872	molecular_function	metal ion binding
B	0061711	molecular_function	tRNA N(6)-L-threonylcarbamoyladenine synthase activity
B	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
B	0106310	molecular_function	protein serine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP A 1531

Chain	Residue
A	LYS12
A	ASP159
A	GLY172
A	PRO173
A	GLU176
A	GLY252
A	VAL253
A	ASN256
A	ASP284
A	HIS106
A	HIS110
A	TYR127
A	SER129
A	GLY130
A	GLY131
A	GLY155
A	LEU158

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ANP B 1533

Chain	Residue
B	ALA10
B	LYS12
B	HIS106
B	HIS110
B	TYR127
B	SER129
B	GLY130
B	GLY131
B	GLY155
B	LEU158
B	ASP159
B	PRO170
B	GLY172
B	PRO173
B	GLU176
B	GLY252
B	VAL253
B	ALA255
B	ASN256
B	GLY283
B	ASP284

---

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VIHnDLTTSNFIF

Chain	Residue	Details
A	VAL447-PHE459

---

site_id	PS01016
Number of Residues	21
Details	GLYCOPROTEASE Glycoprotease family signature. RTlsltLKkPiIgvnHciAHI

Chain	Residue	Details
A	ARG91-ILE111

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor; for kinase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_01447","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01447","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2phk

Chain	Residue	Details
A	THR453
A	ASP451

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2phk

Chain	Residue	Details
B	THR453
B	ASP451

---