2VWB
Structure of the archaeal Kae1-Bud32 fusion protein MJ1130: a model for the eukaryotic EKC-KEOPS subcomplex involved in transcription and telomere homeostasis.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000408 | cellular_component | EKC/KEOPS complex |
| A | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006400 | biological_process | tRNA modification |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061711 | molecular_function | N(6)-L-threonylcarbamoyladenine synthase activity |
| A | 0070525 | biological_process | tRNA threonylcarbamoyladenosine metabolic process |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000408 | cellular_component | EKC/KEOPS complex |
| B | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006400 | biological_process | tRNA modification |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061711 | molecular_function | N(6)-L-threonylcarbamoyladenine synthase activity |
| B | 0070525 | biological_process | tRNA threonylcarbamoyladenosine metabolic process |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ANP A 1531 |
| Chain | Residue |
| A | LYS12 |
| A | ASP159 |
| A | GLY172 |
| A | PRO173 |
| A | GLU176 |
| A | GLY252 |
| A | VAL253 |
| A | ASN256 |
| A | ASP284 |
| A | HIS106 |
| A | HIS110 |
| A | TYR127 |
| A | SER129 |
| A | GLY130 |
| A | GLY131 |
| A | GLY155 |
| A | LEU158 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ANP B 1533 |
| Chain | Residue |
| B | ALA10 |
| B | LYS12 |
| B | HIS106 |
| B | HIS110 |
| B | TYR127 |
| B | SER129 |
| B | GLY130 |
| B | GLY131 |
| B | GLY155 |
| B | LEU158 |
| B | ASP159 |
| B | PRO170 |
| B | GLY172 |
| B | PRO173 |
| B | GLU176 |
| B | GLY252 |
| B | VAL253 |
| B | ALA255 |
| B | ASN256 |
| B | GLY283 |
| B | ASP284 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VIHnDLTTSNFIF |
| Chain | Residue | Details |
| A | VAL447-PHE459 |
| site_id | PS01016 |
| Number of Residues | 21 |
| Details | GLYCOPROTEASE Glycoprotease family signature. RTlsltLKkPiIgvnHciAHI |
| Chain | Residue | Details |
| A | ARG91-ILE111 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for kinase activity => ECO:0000255|HAMAP-Rule:MF_01447 |
| Chain | Residue | Details |
| A | ASP451 | |
| B | ASP451 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | HIS106 | |
| B | TYR127 | |
| B | ASP159 | |
| B | GLU176 | |
| B | ASN256 | |
| B | ASP284 | |
| A | HIS110 | |
| A | TYR127 | |
| A | ASP159 | |
| A | GLU176 | |
| A | ASN256 | |
| A | ASP284 | |
| B | HIS106 | |
| B | HIS110 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01447 |
| Chain | Residue | Details |
| A | GLY172 | |
| A | ILE339 | |
| A | LYS360 | |
| B | GLY172 | |
| B | ILE339 | |
| B | LYS360 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2phk |
| Chain | Residue | Details |
| A | THR453 | |
| A | ASP451 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2phk |
| Chain | Residue | Details |
| B | THR453 | |
| B | ASP451 |
