Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VVL

The structure of MAO-N-D3, a variant of monoamine oxidase from Aspergillus niger.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005777	cellular_component	peroxisome
A	0016491	molecular_function	oxidoreductase activity
A	0097621	molecular_function	monoamine oxidase activity
B	0005777	cellular_component	peroxisome
B	0016491	molecular_function	oxidoreductase activity
B	0097621	molecular_function	monoamine oxidase activity
C	0005777	cellular_component	peroxisome
C	0016491	molecular_function	oxidoreductase activity
C	0097621	molecular_function	monoamine oxidase activity
D	0005777	cellular_component	peroxisome
D	0016491	molecular_function	oxidoreductase activity
D	0097621	molecular_function	monoamine oxidase activity
E	0005777	cellular_component	peroxisome
E	0016491	molecular_function	oxidoreductase activity
E	0097621	molecular_function	monoamine oxidase activity
F	0005777	cellular_component	peroxisome
F	0016491	molecular_function	oxidoreductase activity
F	0097621	molecular_function	monoamine oxidase activity
G	0005777	cellular_component	peroxisome
G	0016491	molecular_function	oxidoreductase activity
G	0097621	molecular_function	monoamine oxidase activity
H	0005777	cellular_component	peroxisome
H	0016491	molecular_function	oxidoreductase activity
H	0097621	molecular_function	monoamine oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	BINDING SITE FOR RESIDUE FAD A 600

Chain	Residue
A	ILE45
A	GLY76
A	ARG77
A	GLY91
A	GLY92
A	THR93
A	TRP94
A	PRO278
A	VAL279
A	THR307
A	ILE308
A	GLY46
A	PRO309
A	TRP420
A	PHE425
A	ALA429
A	TRP430
A	ASN456
A	SER457
A	SER465
A	PHE466
A	ILE467
A	GLY48
A	ALA470
A	HOH2005
A	HOH2083
A	HOH2107
A	HOH2113
A	HOH2118
A	TYR49
A	CYS50
A	GLU69
A	ALA70
A	ARG71
A	GLY75

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 601

Chain	Residue
A	HIS112
A	ASN113
A	ALA114
A	LEU115
E	PHE170
E	ASP173
E	TYR176

site_id	AC3
Number of Residues	33
Details	BINDING SITE FOR RESIDUE FAD B 600

Chain	Residue
B	ILE45
B	GLY46
B	GLY48
B	TYR49
B	CYS50
B	GLU69
B	ALA70
B	ARG71
B	GLY75
B	GLY76
B	ARG77
B	GLY91
B	GLY92
B	THR93
B	TRP94
B	PRO278
B	VAL279
B	THR307
B	PRO309
B	TRP420
B	PHE425
B	ALA429
B	TRP430
B	ASN456
B	SER457
B	SER465
B	PHE466
B	ILE467
B	ALA470
B	HOH2091
B	HOH2097
B	HOH2132
B	HOH2133

site_id	AC4
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD C 600

Chain	Residue
C	SER457
C	SER465
C	PHE466
C	ILE467
C	ALA470
C	HOH2093
C	GLY46
C	GLY48
C	TYR49
C	CYS50
C	GLU69
C	ALA70
C	ARG71
C	GLY75
C	GLY76
C	ARG77
C	GLY91
C	GLY92
C	THR93
C	TRP94
C	PRO278
C	VAL279
C	THR307
C	ILE308
C	PRO309
C	TRP420
C	PHE425
C	ALA429
C	TRP430
C	ASN456

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 601

Chain	Residue
C	ASN120
C	ARG123
C	ARG351
C	THR371

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 602

Chain	Residue
B	PHE170
B	ASP173
B	TYR176
C	HIS112
C	ASN113
C	ALA114
C	LEU115

site_id	AC7
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD D 600

Chain	Residue
D	ILE45
D	GLY46
D	GLY48
D	TYR49
D	CYS50
D	GLU69
D	ALA70
D	ARG71
D	GLY75
D	GLY76
D	ARG77
D	GLY91
D	GLY92
D	THR93
D	TRP94
D	PRO278
D	VAL279
D	THR307
D	ILE308
D	PRO309
D	ILE316
D	PHE425
D	ALA429
D	TRP430
D	ASN456
D	SER457
D	SER465
D	PHE466
D	ILE467
D	ALA470
D	HOH2098
D	HOH2102

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 601

Chain	Residue
D	HIS112
D	ASN113
D	ALA114
D	LEU115
H	PHE170
H	ASP173
H	TYR176

site_id	AC9
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD E 600

Chain	Residue
E	ILE45
E	GLY46
E	GLY48
E	TYR49
E	CYS50
E	GLU69
E	ALA70
E	ARG71
E	GLY75
E	GLY76
E	ARG77
E	GLY91
E	GLY92
E	THR93
E	TRP94
E	PRO278
E	VAL279
E	THR307
E	ILE308
E	PRO309
E	TRP420
E	PHE425
E	ALA429
E	TRP430
E	ASN456
E	SER457
E	SER465
E	PHE466
E	ILE467
E	ALA470
E	HOH2006
E	HOH2075
E	HOH2117
E	HOH2122

site_id	BC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD F 600

Chain	Residue
F	ILE45
F	GLY46
F	GLY48
F	TYR49
F	CYS50
F	GLU69
F	ALA70
F	ARG71
F	GLY76
F	ARG77
F	GLY91
F	GLY92
F	THR93
F	TRP94
F	PRO278
F	VAL279
F	THR307
F	PRO309
F	TRP420
F	PHE425
F	TRP430
F	ASN456
F	SER457
F	SER465
F	PHE466
F	ILE467
F	ALA470
F	HOH2073
F	HOH2075
F	HOH2102
F	HOH2103

site_id	BC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD G 600

Chain	Residue
G	GLY46
G	GLY48
G	TYR49
G	CYS50
G	GLU69
G	ALA70
G	ARG71
G	GLY75
G	GLY76
G	ARG77
G	GLY91
G	GLY92
G	THR93
G	TRP94
G	PRO278
G	VAL279
G	ILE308
G	PRO309
G	TRP420
G	PHE425
G	ALA429
G	TRP430
G	ASN456
G	SER457
G	SER465
G	PHE466
G	ILE467
G	ALA470
G	HOH2051

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 601

Chain	Residue
F	ASN120
F	ARG123
F	ARG351
F	THR371

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO G 602

Chain	Residue
F	HIS112
F	ASN113
F	ALA114
F	LEU115
G	PHE170
G	ASP173
G	TYR176

site_id	BC5
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD H 600

Chain	Residue
H	ILE45
H	GLY46
H	GLY48
H	TYR49
H	CYS50
H	GLU69
H	ALA70
H	ARG71
H	GLY75
H	GLY76
H	ARG77
H	GLY91
H	GLY92
H	THR93
H	TRP94
H	PRO278
H	VAL279
H	THR307
H	ILE308
H	PRO309
H	TRP420
H	PHE425
H	ALA429
H	TRP430
H	ASN456
H	SER457
H	SER465
H	PHE466
H	ILE467
H	ALA470
H	HOH2058
H	HOH2075
H	HOH2079
H	HOH2080

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
G	HIS229
G	LYS340

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
A	HIS96

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
B	HIS96

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
C	HIS96

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
D	HIS96

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
E	HIS96

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
F	HIS96

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
H	HIS96

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
A	HIS229
A	LYS340

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
B	HIS229
B	LYS340

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
C	HIS229
C	LYS340

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
D	HIS229
D	LYS340

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
E	HIS229
E	LYS340

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
F	HIS229
F	LYS340

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
H	HIS229
H	LYS340

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
G	HIS96

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)