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2VSO

Crystal Structure of a Translation Initiation Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002183biological_processcytoplasmic translational initiation
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003743molecular_functiontranslation initiation factor activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005840cellular_componentribosome
A0005886cellular_componentplasma membrane
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0006446biological_processregulation of translational initiation
A0008186molecular_functionATP-dependent activity, acting on RNA
A0010494cellular_componentcytoplasmic stress granule
A0016281cellular_componenteukaryotic translation initiation factor 4F complex
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A1901195biological_processpositive regulation of formation of translation preinitiation complex
B0002183biological_processcytoplasmic translational initiation
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003743molecular_functiontranslation initiation factor activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005840cellular_componentribosome
B0005886cellular_componentplasma membrane
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0006446biological_processregulation of translational initiation
B0008186molecular_functionATP-dependent activity, acting on RNA
B0010494cellular_componentcytoplasmic stress granule
B0016281cellular_componenteukaryotic translation initiation factor 4F complex
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B1901195biological_processpositive regulation of formation of translation preinitiation complex
E0003723molecular_functionRNA binding
E0003743molecular_functiontranslation initiation factor activity
F0003723molecular_functionRNA binding
F0003743molecular_functiontranslation initiation factor activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE AMP A1394
ChainResidue
APHE42
AGLU44
AGLN49
AGLY69
ATHR70
AGLY71
ALYS72
ATHR73

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE AMP B1394
ChainResidue
BGLU44
BGLN49
BGLY69
BTHR70
BGLY71
BLYS72
BTHR73
BHOH2027
BHOH2028
BPHE42

Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. ILDEADEmL
ChainResidueDetails
AILE168-LEU176

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AALA66
BALA66

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000269|PubMed:9298649, ECO:0007744|PubMed:22814378
ChainResidueDetails
ASER2
BSER2

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ATHR73
BTHR73

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ASER77
BSER77

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
ASER129
BSER129

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
ATHR146
BTHR146

226707

PDB entries from 2024-10-30

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