2VSO
Crystal Structure of a Translation Initiation Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002183 | biological_process | cytoplasmic translational initiation |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005840 | cellular_component | ribosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006413 | biological_process | translational initiation |
| A | 0006446 | biological_process | regulation of translational initiation |
| A | 0008186 | molecular_function | ATP-dependent activity, acting on RNA |
| A | 0010467 | biological_process | gene expression |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0016281 | cellular_component | eukaryotic translation initiation factor 4F complex |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 1901195 | biological_process | positive regulation of formation of translation preinitiation complex |
| B | 0002183 | biological_process | cytoplasmic translational initiation |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0003743 | molecular_function | translation initiation factor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005840 | cellular_component | ribosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006413 | biological_process | translational initiation |
| B | 0006446 | biological_process | regulation of translational initiation |
| B | 0008186 | molecular_function | ATP-dependent activity, acting on RNA |
| B | 0010467 | biological_process | gene expression |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0016281 | cellular_component | eukaryotic translation initiation factor 4F complex |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 1901195 | biological_process | positive regulation of formation of translation preinitiation complex |
| E | 0003723 | molecular_function | RNA binding |
| F | 0003723 | molecular_function | RNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE AMP A1394 |
| Chain | Residue |
| A | PHE42 |
| A | GLU44 |
| A | GLN49 |
| A | GLY69 |
| A | THR70 |
| A | GLY71 |
| A | LYS72 |
| A | THR73 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AMP B1394 |
| Chain | Residue |
| B | GLU44 |
| B | GLN49 |
| B | GLY69 |
| B | THR70 |
| B | GLY71 |
| B | LYS72 |
| B | THR73 |
| B | HOH2027 |
| B | HOH2028 |
| B | PHE42 |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. ILDEADEmL |
| Chain | Residue | Details |
| A | ILE168-LEU176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Motif: {"description":"Q motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEAD box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
