2VPG
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0008013 | molecular_function | beta-catenin binding |
| B | 0060070 | biological_process | canonical Wnt signaling pathway |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0008013 | molecular_function | beta-catenin binding |
| D | 0060070 | biological_process | canonical Wnt signaling pathway |
| P | 0000786 | cellular_component | nucleosome |
| P | 0003677 | molecular_function | DNA binding |
| P | 0030527 | molecular_function | structural constituent of chromatin |
| R | 0000786 | cellular_component | nucleosome |
| R | 0003677 | molecular_function | DNA binding |
| R | 0030527 | molecular_function | structural constituent of chromatin |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1399 |
| Chain | Residue |
| A | GLN354 |
| A | HIS368 |
| A | HOH2092 |
| A | HOH2093 |
| C | GLY336 |
| C | ASN348 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1399 |
| Chain | Residue |
| C | CYS371 |
| C | CYS343 |
| C | CYS346 |
| C | HIS368 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1400 |
| Chain | Residue |
| C | CYS359 |
| C | CYS363 |
| C | CYS392 |
| C | CYS395 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1400 |
| Chain | Residue |
| A | CYS343 |
| A | CYS346 |
| A | HIS368 |
| A | CYS371 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1401 |
| Chain | Residue |
| A | CYS359 |
| A | CYS363 |
| A | CYS392 |
| A | CYS395 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 53 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CgiCtnevnddqda...................................IlCeas.Cqkw.FHriCtgmtetayglltaeasav...........................WgCdtC |
| Chain | Residue | Details |
| A | CYS343-CYS395 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| P | DA22 | |
| R | DA22 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| P | THR3 | |
| R | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | MLY4 | |
| R | MLY4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| P | GLN5 | |
| R | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| P | THR6 | |
| R | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| P | ARG8 | |
| R | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | LYS9 | |
| R | LYS9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| P | SER10 | |
| R | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| P | THR11 | |
| R | THR11 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| P | LYS14 | |
| R | LYS14 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| P | ARG17 | |
| R | ARG17 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | LYS18 | |
| R | LYS18 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| P | LYS18 | |
| R | LYS18 |
