2VPB

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003713	molecular_function	transcription coactivator activity
B	0008013	molecular_function	beta-catenin binding
B	0060070	biological_process	canonical Wnt signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A1398

Chain	Residue
A	LEU382
A	GLU385
A	ALA388
A	HOH2055
A	HOH2061
A	HOH2062

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A1399

Chain	Residue
A	HOH2003
A	LEU358
A	GLU360
A	TRP390

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1400

Chain	Residue
A	CYS343
A	CYS346
A	HIS368
A	CYS371

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1401

Chain	Residue
A	CYS359
A	CYS363
A	CYS392
A	CYS395

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	53
Details	ZF_PHD_1 Zinc finger PHD-type signature. CgiCtnevnddqda...................................IlCeas.Cqkw.FHriCtgmtetayglltaeasav...........................WgCdtC

Chain	Residue	Details
A	CYS343-CYS395

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	47
Details	Region: {"description":"Interaction with H3K4me2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Region: {"description":"Interaction with BCL9","evidences":[{"source":"PubMed","id":"18498752","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Region: {"description":"Interaction with PYGO1"}

Chain

Residue

Details

---