2VOJ
Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0000286 | molecular_function | alanine dehydrogenase activity |
A | 0001666 | biological_process | response to hypoxia |
A | 0005576 | cellular_component | extracellular region |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006524 | biological_process | alanine catabolic process |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042853 | biological_process | L-alanine catabolic process |
A | 0046872 | molecular_function | metal ion binding |
C | 0000166 | molecular_function | nucleotide binding |
C | 0000286 | molecular_function | alanine dehydrogenase activity |
C | 0001666 | biological_process | response to hypoxia |
C | 0005576 | cellular_component | extracellular region |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0006524 | biological_process | alanine catabolic process |
C | 0009274 | cellular_component | peptidoglycan-based cell wall |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0042853 | biological_process | L-alanine catabolic process |
C | 0046872 | molecular_function | metal ion binding |
E | 0000166 | molecular_function | nucleotide binding |
E | 0000286 | molecular_function | alanine dehydrogenase activity |
E | 0001666 | biological_process | response to hypoxia |
E | 0005576 | cellular_component | extracellular region |
E | 0005829 | cellular_component | cytosol |
E | 0005886 | cellular_component | plasma membrane |
E | 0006524 | biological_process | alanine catabolic process |
E | 0009274 | cellular_component | peptidoglycan-based cell wall |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0042853 | biological_process | L-alanine catabolic process |
E | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAD A 500 |
Chain | Residue |
A | LEU130 |
A | LYS203 |
A | SER220 |
A | ALA238 |
A | VAL239 |
A | LEU240 |
A | ILE267 |
A | ASP270 |
A | ASN300 |
A | MET301 |
A | PRO302 |
A | MET133 |
A | 2OP501 |
A | HOH2063 |
A | HOH2064 |
A | HOH2065 |
A | SER134 |
A | ALA137 |
A | GLY177 |
A | THR178 |
A | ALA179 |
A | ASP198 |
A | ILE199 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 2OP A 501 |
Chain | Residue |
A | ARG15 |
A | LYS75 |
A | PHE94 |
A | HIS96 |
A | MET133 |
A | PRO302 |
A | NAD500 |
site_id | AC3 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAD C 500 |
Chain | Residue |
C | LEU130 |
C | MET133 |
C | SER134 |
C | GLY177 |
C | THR178 |
C | ALA179 |
C | ASP198 |
C | LYS203 |
C | SER220 |
C | ALA238 |
C | VAL239 |
C | LEU240 |
C | LEU249 |
C | ILE267 |
C | ASP270 |
C | ASN300 |
C | MET301 |
C | PRO302 |
C | 2OP501 |
C | HOH2035 |
C | HOH2047 |
C | HOH2048 |
C | HOH2049 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 2OP C 501 |
Chain | Residue |
C | ARG15 |
C | LYS75 |
C | PHE94 |
C | HIS96 |
C | MET133 |
C | PRO302 |
C | NAD500 |
site_id | AC5 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD E 500 |
Chain | Residue |
E | LEU130 |
E | MET133 |
E | SER134 |
E | GLY177 |
E | THR178 |
E | ALA179 |
E | ASP198 |
E | LYS203 |
E | SER220 |
E | ALA238 |
E | VAL239 |
E | LEU240 |
E | ILE267 |
E | ALA268 |
E | ASP270 |
E | ASN300 |
E | MET301 |
E | PRO302 |
E | 2OP501 |
E | HOH2030 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 2OP E 501 |
Chain | Residue |
E | ARG15 |
E | LYS75 |
E | HIS96 |
E | MET133 |
E | ASP270 |
E | ASN300 |
E | PRO302 |
E | NAD500 |
Functional Information from PROSITE/UniProt
site_id | PS00836 |
Number of Residues | 27 |
Details | ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. GIPtEtknNEf..RVAiTPaGVaeLtRrG |
Chain | Residue | Details |
A | GLY4-GLY30 |
site_id | PS00837 |
Number of Residues | 26 |
Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VIGAGtAGynAariAnGMGAtVtvlD |
Chain | Residue | Details |
A | VAL173-ASP198 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:18304579 |
Chain | Residue | Details |
A | HIS96 | |
A | ASP270 | |
C | HIS96 | |
C | ASP270 | |
E | HIS96 | |
E | ASP270 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18304579 |
Chain | Residue | Details |
A | ARG15 | |
A | LYS75 | |
C | ARG15 | |
C | LYS75 | |
E | ARG15 | |
E | LYS75 |
site_id | SWS_FT_FI3 |
Number of Residues | 27 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18304579, ECO:0000269|PubMed:18491387 |
Chain | Residue | Details |
A | SER134 | |
C | SER134 | |
C | THR178 | |
C | ASP198 | |
C | LYS203 | |
C | SER220 | |
C | VAL239 | |
C | ILE267 | |
C | ARG279 | |
C | VAL298 | |
E | SER134 | |
A | THR178 | |
E | THR178 | |
E | ASP198 | |
E | LYS203 | |
E | SER220 | |
E | VAL239 | |
E | ILE267 | |
E | ARG279 | |
E | VAL298 | |
A | ASP198 | |
A | LYS203 | |
A | SER220 | |
A | VAL239 | |
A | ILE267 | |
A | ARG279 | |
A | VAL298 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18304579, ECO:0007744|PDB:2VHX |
Chain | Residue | Details |
A | GLU323 | |
A | HIS327 | |
C | GLU323 | |
C | HIS327 | |
E | GLU323 | |
E | HIS327 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1pjb |
Chain | Residue | Details |
A | GLU118 | |
A | LYS75 | |
A | ASP270 | |
A | HIS96 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1pjb |
Chain | Residue | Details |
C | GLU118 | |
C | LYS75 | |
C | ASP270 | |
C | HIS96 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1pjb |
Chain | Residue | Details |
E | GLU118 | |
E | LYS75 | |
E | ASP270 | |
E | HIS96 |