2VOJ

Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000286	molecular_function	alanine dehydrogenase activity
A	0001666	biological_process	response to hypoxia
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006524	biological_process	alanine catabolic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016491	molecular_function	oxidoreductase activity
A	0042853	biological_process	L-alanine catabolic process
A	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000286	molecular_function	alanine dehydrogenase activity
C	0001666	biological_process	response to hypoxia
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006524	biological_process	alanine catabolic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016491	molecular_function	oxidoreductase activity
C	0042853	biological_process	L-alanine catabolic process
C	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000286	molecular_function	alanine dehydrogenase activity
E	0001666	biological_process	response to hypoxia
E	0005576	cellular_component	extracellular region
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006524	biological_process	alanine catabolic process
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0016491	molecular_function	oxidoreductase activity
E	0042853	biological_process	L-alanine catabolic process
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD A 500

Chain	Residue
A	LEU130
A	LYS203
A	SER220
A	ALA238
A	VAL239
A	LEU240
A	ILE267
A	ASP270
A	ASN300
A	MET301
A	PRO302
A	MET133
A	2OP501
A	HOH2063
A	HOH2064
A	HOH2065
A	SER134
A	ALA137
A	GLY177
A	THR178
A	ALA179
A	ASP198
A	ILE199

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 2OP A 501

Chain	Residue
A	ARG15
A	LYS75
A	PHE94
A	HIS96
A	MET133
A	PRO302
A	NAD500

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD C 500

Chain	Residue
C	LEU130
C	MET133
C	SER134
C	GLY177
C	THR178
C	ALA179
C	ASP198
C	LYS203
C	SER220
C	ALA238
C	VAL239
C	LEU240
C	LEU249
C	ILE267
C	ASP270
C	ASN300
C	MET301
C	PRO302
C	2OP501
C	HOH2035
C	HOH2047
C	HOH2048
C	HOH2049

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 2OP C 501

Chain	Residue
C	ARG15
C	LYS75
C	PHE94
C	HIS96
C	MET133
C	PRO302
C	NAD500

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD E 500

Chain	Residue
E	LEU130
E	MET133
E	SER134
E	GLY177
E	THR178
E	ALA179
E	ASP198
E	LYS203
E	SER220
E	ALA238
E	VAL239
E	LEU240
E	ILE267
E	ALA268
E	ASP270
E	ASN300
E	MET301
E	PRO302
E	2OP501
E	HOH2030

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2OP E 501

Chain	Residue
E	ARG15
E	LYS75
E	HIS96
E	MET133
E	ASP270
E	ASN300
E	PRO302
E	NAD500

---

Functional Information from PROSITE/UniProt

site_id	PS00836
Number of Residues	27
Details	ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. GIPtEtknNEf..RVAiTPaGVaeLtRrG

Chain	Residue	Details
A	GLY4-GLY30

---

site_id	PS00837
Number of Residues	26
Details	ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VIGAGtAGynAariAnGMGAtVtvlD

Chain	Residue	Details
A	VAL173-ASP198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	39
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18491387","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VHX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
A	GLU118
A	LYS75
A	ASP270
A	HIS96

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
C	GLU118
C	LYS75
C	ASP270
C	HIS96

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
E	GLU118
E	LYS75
E	ASP270
E	HIS96

---