2VNF
MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 300 |
| Chain | Residue |
| A | GLN244 |
| A | DTT1245 |
| A | HOH2058 |
| A | HOH2059 |
| A | HOH2061 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DTT A 1245 |
| Chain | Residue |
| A | HOH2007 |
| A | HOH2025 |
| A | HOH2048 |
| A | HOH2057 |
| A | HOH2060 |
| A | HOH2061 |
| A | CYS199 |
| A | HIS202 |
| A | ILE219 |
| A | NA300 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DTU C 1246 |
| Chain | Residue |
| C | HIS202 |
| C | ASN214 |
| C | GLN244 |
| C | HOH2031 |
| C | HOH2036 |
| C | HOH2039 |
| C | HOH2040 |
| C | HOH2041 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1246 |
| Chain | Residue |
| A | CYS199 |
| A | CYS201 |
| A | HIS223 |
| A | CYS226 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1247 |
| Chain | Residue |
| C | CYS199 |
| C | CYS201 |
| C | HIS223 |
| C | CYS226 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1248 |
| Chain | Residue |
| C | CYS212 |
| C | CYS217 |
| C | CYS239 |
| C | CYS242 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1247 |
| Chain | Residue |
| A | CYS212 |
| A | CYS217 |
| A | CYS239 |
| A | CYS242 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 44 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. Cl.Chqvsygem.....................................IgCdnpdCsiewFHfaCvglttkprgk...................................WfCprC |
| Chain | Residue | Details |
| A | CYS199-CYS242 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| B | ARG2 | |
| D | ARG2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088 |
| Chain | Residue | Details |
| B | THR3 | |
| C | CYS201 | |
| C | CYS212 | |
| C | CYS217 | |
| C | HIS223 | |
| C | CYS226 | |
| C | CYS239 | |
| C | CYS242 | |
| D | THR3 | |
| A | CYS212 | |
| A | CYS217 | |
| A | HIS223 | |
| A | CYS226 | |
| A | CYS239 | |
| A | CYS242 | |
| C | CYS199 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | M3L4 | |
| D | M3L4 | |
| A | ASP213 | |
| A | TRP221 | |
| C | TYR198 | |
| C | MET209 | |
| C | ASP213 | |
| C | TRP221 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| B | GLN5 | |
| D | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| B | THR6 | |
| D | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| B | ARG8 | |
| D | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS9 | |
| D | LYS9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| B | SER10 | |
| D | SER10 |
