Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2VKE

Tet repressor class D complexed with cobalt and tetracycline

Functional Information from GO Data
ChainGOidnamespacecontents
A0000976molecular_functiontranscription cis-regulatory region binding
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0006355biological_processregulation of DNA-templated transcription
A0045892biological_processnegative regulation of DNA-templated transcription
A0046677biological_processresponse to antibiotic
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE TAC A 222
ChainResidue
AHIS64
AGLN116
ASER138
AMET177
ACO223
AHOH224
AHOH225
AHOH226
AHOH2108
ASER67
AASN82
APHE86
AHIS100
ATHR103
AARG104
APRO105
AVAL113

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CO A 223
ChainResidue
AHIS100
ATAC222
AHOH224
AHOH225
AHOH226

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1227
ChainResidue
ASER2
AARG3
ASER74
ASER77

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1228
ChainResidue
AARG3
ALEU4
AGLN76
AARG80
AHOH2098

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1229
ChainResidue
ATRP75
AGLN76

Functional Information from PROSITE/UniProt
site_idPS01081
Number of Residues32
DetailsHTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL
ChainResidueDetails
AGLY21-LEU52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19
DetailsDNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335
ChainResidueDetails
ATHR26-VAL45

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:8153629, ECO:0007744|PDB:2TRT
ChainResidueDetails
AHIS64
AASN82
AHIS100

238268

PDB entries from 2025-07-02

PDB statisticsPDBj update infoContact PDBjnumon