2VJK
Formyl-CoA transferase with aspartyl-CoA thioester intermediate derived from oxalyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008410 | molecular_function | CoA-transferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0033608 | molecular_function | formyl-CoA transferase activity |
| A | 0033611 | biological_process | oxalate catabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008410 | molecular_function | CoA-transferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0033608 | molecular_function | formyl-CoA transferase activity |
| B | 0033611 | biological_process | oxalate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE COA A1169 |
| Chain | Residue |
| A | HIS15 |
| A | GLY98 |
| A | ALA101 |
| A | ARG104 |
| A | MET105 |
| A | VAL124 |
| A | LYS137 |
| A | VAL138 |
| A | TYR139 |
| A | ASP169 |
| A | MET200 |
| A | GLN17 |
| A | HOH2177 |
| A | HOH2178 |
| A | HOH2179 |
| A | HOH2180 |
| B | ASN287 |
| A | ALA18 |
| A | ARG38 |
| A | LEU72 |
| A | MET74 |
| A | LYS75 |
| A | ASN96 |
| A | PHE97 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE COA B1169 |
| Chain | Residue |
| A | GLY260 |
| A | CL1432 |
| B | HIS15 |
| B | VAL16 |
| B | GLN17 |
| B | ARG38 |
| B | LEU72 |
| B | ASP73 |
| B | MET74 |
| B | LYS75 |
| B | PHE97 |
| B | GLY98 |
| B | ARG104 |
| B | MET105 |
| B | TYR139 |
| B | GLU140 |
| B | ASP169 |
| B | HOH2183 |
| B | HOH2184 |
| B | HOH2185 |
| B | HOH2186 |
| B | HOH2187 |
| B | HOH2188 |
| B | HOH2214 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A1430 |
| Chain | Residue |
| A | PHE63 |
| A | ALA166 |
| A | SER170 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A1431 |
| Chain | Residue |
| A | ASP294 |
| A | ASP297 |
| A | HOH2291 |
| A | HOH2293 |
| A | HOH2295 |
| A | HOH2429 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B1430 |
| Chain | Residue |
| B | GLN17 |
| B | ALA18 |
| B | ASP169 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A1432 |
| Chain | Residue |
| A | GLY261 |
| A | GLN262 |
| A | HOH2263 |
| B | TYR139 |
| B | COA1169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00742, ECO:0000269|PubMed:15213226 |
| Chain | Residue | Details |
| A | ASP169 | |
| B | ASP169 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS15 | |
| B | GLY260 | |
| A | LEU72 | |
| A | ASN96 | |
| A | LYS137 | |
| A | GLY260 | |
| B | HIS15 | |
| B | LEU72 | |
| B | ASN96 | |
| B | LYS137 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00742, ECO:0000269|PubMed:12839984, ECO:0000269|PubMed:15213226, ECO:0000269|PubMed:18162462 |
| Chain | Residue | Details |
| A | ARG38 | |
| A | ARG104 | |
| B | ARG38 | |
| B | ARG104 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xvt |
| Chain | Residue | Details |
| A | ASP169 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xvt |
| Chain | Residue | Details |
| B | ASP169 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 155 |
| Chain | Residue | Details |
| A | GLN17 | electrostatic stabiliser, hydrogen bond donor |
| A | GLU140 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP169 | covalently attached, electrofuge, electrophile, nucleofuge, nucleophile |
| A | GLY260 | electrostatic stabiliser, hydrogen bond acceptor |
| A | GLY261 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 155 |
| Chain | Residue | Details |
| B | GLN17 | electrostatic stabiliser, hydrogen bond donor |
| B | GLU140 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP169 | covalently attached, electrofuge, electrophile, nucleofuge, nucleophile |
| B | GLY260 | electrostatic stabiliser, hydrogen bond acceptor |
| B | GLY261 | electrostatic stabiliser, hydrogen bond donor |
