2VGZ

CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006536	biological_process	glutamate metabolic process
A	0008483	molecular_function	transaminase activity
A	0009058	biological_process	biosynthetic process
A	0016212	molecular_function	kynurenine-oxoglutarate transaminase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
A	0042803	molecular_function	protein homodimerization activity
A	0047315	molecular_function	kynurenine-glyoxylate transaminase activity
A	0047536	molecular_function	2-aminoadipate transaminase activity
A	0047958	molecular_function	glycine:2-oxoglutarate aminotransferase activity
A	0050094	molecular_function	methionine-glyoxylate transaminase activity
A	0070189	biological_process	kynurenine metabolic process
A	1901605	biological_process	alpha-amino acid metabolic process
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006536	biological_process	glutamate metabolic process
B	0008483	molecular_function	transaminase activity
B	0009058	biological_process	biosynthetic process
B	0016212	molecular_function	kynurenine-oxoglutarate transaminase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
B	0042803	molecular_function	protein homodimerization activity
B	0047315	molecular_function	kynurenine-glyoxylate transaminase activity
B	0047536	molecular_function	2-aminoadipate transaminase activity
B	0047958	molecular_function	glycine:2-oxoglutarate aminotransferase activity
B	0050094	molecular_function	methionine-glyoxylate transaminase activity
B	0070189	biological_process	kynurenine metabolic process
B	1901605	biological_process	alpha-amino acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP A 1263

Chain	Residue
A	GLY116
A	ARG270
A	HOH2154
B	TYR74
A	SER117
A	GLN118
A	TYR142
A	ASN202
A	TYR233
A	SER260
A	SER262
A	LYS263

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP B 1263

Chain	Residue
A	TYR74
B	GLY116
B	SER117
B	GLN118
B	TYR142
B	ASN202
B	PRO232
B	TYR233
B	SER260
B	SER262
B	LYS263
B	ARG270

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 1426

Chain	Residue
A	GLN119
A	LYS123
B	GLN119
B	LYS123

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING:

Chain	Residue	Details
A	ARG20
B	ARG399
A	TYR74
A	TYR142
A	ASN202
A	ARG399
B	ARG20
B	TYR74
B	TYR142
B	ASN202

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site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM8

Chain	Residue	Details
A	LYS69
A	LYS179
A	LYS422
B	LYS69
B	LYS179
B	LYS422

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site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WVM8

Chain	Residue	Details
A	LYS263
A	LYS339
A	LYS367
B	LYS263
B	LYS339
B	LYS367

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
A	TYR142
A	ASP230

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
B	TYR142
B	ASP230

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