2VG8

Characterization and engineering of the bifunctional N- and O- glucosyltransferase involved in xenobiotic metabolism in plants

Replaces:  2VCU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006805	biological_process	xenobiotic metabolic process
A	0008194	molecular_function	UDP-glycosyltransferase activity
A	0009507	cellular_component	chloroplast
A	0009636	biological_process	response to toxic substance
A	0009809	biological_process	lignin biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0035251	molecular_function	UDP-glucosyltransferase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0050505	molecular_function	hydroquinone glucosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE UDP A1477

Chain	Residue
A	GLY18
A	GLY366
A	TRP367
A	ASN368
A	SER369
A	GLU372
A	TYR386
A	TRS1478
A	HOH2006
A	HOH2223
A	HOH2275
A	ILE21
A	HOH2350
A	HOH2353
A	GLY276
A	SER277
A	VAL303
A	TRP346
A	ALA347
A	GLN349
A	HIS364

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TRS A1478

Chain	Residue
A	GLY18
A	HIS19
A	PRO139
A	GLY366
A	TRP367
A	ALA387
A	GLU388
A	UDP1477
A	EDO1480
A	HOH2007
A	HOH2351
A	HOH2353

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A1479

Chain	Residue
A	TRP383
A	PRO384
A	VAL414
A	HOH2291
A	HOH2297
A	HOH2352

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A1480

Chain	Residue
A	HIS19
A	ILE86
A	TYR315
A	ALA387
A	TRS1478
A	HOH2353

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A1481

Chain	Residue
A	PHE275
A	THR280
A	LEU281
A	TRP302
A	VAL303
A	ILE304
A	ARG305
A	HOH2354

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A1482

Chain	Residue
A	HIS34
A	LEU328
A	PRO330
A	SER461
A	LYS468

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A1483

Chain	Residue
A	ILE42
A	ALA43
A	GLY44
A	GLY46
A	PHE67
A	LEU68
A	PRO69
A	PRO70
A	EDO1484
A	HOH2355

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A1484

Chain	Residue
A	GLY46
A	PRO47
A	PRO70
A	EDO1483
A	HOH2026
A	HOH2355

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A1485

Chain	Residue
A	SER159
A	GLU161
A	LYS443
A	CYS447

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A1486

Chain	Residue
A	PRO152
A	LYS202
A	LYS205
A	GLU334
A	ARG335
A	HOH2247
A	HOH2356

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A1487

Chain	Residue
A	GLY173
A	ASN221
A	ASP399
A	HOH2281
A	HOH2357

---

Functional Information from PROSITE/UniProt

site_id	PS00375
Number of Residues	44
Details	UDPGT UDP-glycosyltransferases signature. WapQaqVLahpstgGFLTHCGwnStleSVvsgi.PLiawPlyaEQ

Chain	Residue	Details
A	TRP346-GLN389

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"A0A0A1HA03","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Charge relay","evidences":[{"source":"UniProtKB","id":"A0A0A1HA03","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18077347","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VCE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---