2VFE

Crystal structure of F96S mutant of Plasmodium falciparum triosephosphate isomerase with 3- phosphoglycerate bound at the dimer interface

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0042802	molecular_function	identical protein binding
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0042802	molecular_function	identical protein binding
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 3PG A 1249

Chain	Residue
A	ASN65
A	HOH2104
A	HOH2105
A	HOH2106
B	TYR101
B	PHE102
B	HIS103
A	LYS68
A	ARG98
A	PHE102
A	HIS103
A	GLU104
A	ASP108
A	LYS112
A	HOH2047

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1250

Chain	Residue
A	LYS12
A	GLY209
A	GLY210
A	SER211
A	LEU230
A	GLY232
A	HOH2101
A	HOH2107

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 3PG B 1249

Chain	Residue
A	TYR101
A	PHE102
A	HIS103
A	HOH2104
A	HOH2105
B	ASN65
B	LYS68
B	ARG98
B	PHE102
B	HIS103
B	GLU104
B	ASP108
B	LYS112
B	HOH2153
B	HOH2154

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 1250

Chain	Residue
B	LYS12
B	GLY210
B	SER211
B	GLY232
B	ASN233
B	HOH2155
B	HOH2156
B	HOH2157

---

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. VYEPLWAIGTG

Chain	Residue	Details
A	VAL163-GLY173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Electrophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
A	ASN10
A	HIS95
A	GLU165
A	GLY171
A	LYS12

---

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
B	ASN10
B	HIS95
B	GLU165
B	GLY171
B	LYS12

---