2VDW

Guanosine N7 methyl-transferase sub-complex (D1-D12) of the vaccinia virus mRNA capping enzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0006351	biological_process	DNA-templated transcription
B	0006353	biological_process	DNA-templated transcription termination
B	0006370	biological_process	7-methylguanosine mRNA capping
B	0006397	biological_process	mRNA processing
B	0044423	cellular_component	virion component
B	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
C	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0005515	molecular_function	protein binding
D	0006351	biological_process	DNA-templated transcription
D	0006353	biological_process	DNA-templated transcription termination
D	0006370	biological_process	7-methylguanosine mRNA capping
D	0006397	biological_process	mRNA processing
D	0044423	cellular_component	virion component
D	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
E	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
F	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
F	0005515	molecular_function	protein binding
F	0006351	biological_process	DNA-templated transcription
F	0006353	biological_process	DNA-templated transcription termination
F	0006370	biological_process	7-methylguanosine mRNA capping
F	0006397	biological_process	mRNA processing
F	0044423	cellular_component	virion component
F	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
G	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
H	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
H	0005515	molecular_function	protein binding
H	0006351	biological_process	DNA-templated transcription
H	0006353	biological_process	DNA-templated transcription termination
H	0006370	biological_process	7-methylguanosine mRNA capping
H	0006397	biological_process	mRNA processing
H	0044423	cellular_component	virion component
H	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1845

Chain	Residue
A	ARG560
A	ARG562
A	ASN601
A	ALA603
A	ARG632

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C1845

Chain	Residue
C	ARG560
C	ARG562
C	ASN601
C	ARG632

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C1847

Chain	Residue
D	TYR152
D	ARG180
D	SER199

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E1845

Chain	Residue
E	ARG560
E	ARG562
E	ASN601
E	ALA603
E	ARG632

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G1845

Chain	Residue
G	ARG560
G	ARG562
G	ASN601
G	ALA603
G	ARG632

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H1288

Chain	Residue
H	SER269
H	ASN276
H	LYS277
H	SO41289

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H1289

Chain	Residue
H	SER265
H	SER269
H	ASP270
H	LYS277
H	HIS278
H	SO41288

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H1290

Chain	Residue
H	LYS277
H	ARG281

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H1291

Chain	Residue
H	LYS277
H	ARG280

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F1288

Chain	Residue
F	SER269
F	ASN276
F	LYS277
F	SO41289

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F1289

Chain	Residue
F	SER265
F	SER269
F	ASP270
F	HIS278
F	SO41288

---

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A1846

Chain	Residue
A	ARG548
A	LEU549
A	ASN550
A	TYR555
A	PHE556
A	LYS573
A	ASP598
A	PHE599
A	GLY600
A	ALA603
A	ASP620
A	PRO621
A	ARG655
A	GLN678
A	PHE679
A	ALA680

---

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH G1846

Chain	Residue
G	ARG548
G	LEU549
G	ASN550
G	LYS573
G	ASP598
G	PHE599
G	GLY600
G	ALA603
G	ASP620
G	ASP622
G	ARG655
G	GLN678
G	TYR683

---

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH E1846

Chain	Residue
E	ARG548
E	LEU549
E	ASN550
E	TYR555
E	PHE556
E	LYS573
E	ASP598
E	PHE599
E	GLY600
E	ALA603
E	ASP620
E	ARG655
E	GLN678
E	PHE679
E	TYR683

---

site_id	BC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH C1846

Chain	Residue
C	ASP620
C	PRO621
C	ASP622
C	ARG655
C	GLN678
C	PHE679
C	TYR683
C	ARG548
C	LEU549
C	ASN550
C	TYR555
C	PHE556
C	LYS573
C	ASP598
C	PHE599
C	GLY600
C	ALA603

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---