2VDE
Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0019867 | cellular_component | outer membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0019867 | cellular_component | outer membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0019867 | cellular_component | outer membrane |
| C | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A1453 |
| Chain | Residue |
| A | ARG249 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A1454 |
| Chain | Residue |
| A | GLY318 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B1453 |
| Chain | Residue |
| B | GLN316 |
| B | GLY318 |
| B | MET319 |
| B | VAL320 |
| B | ASN321 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL C1453 |
| Chain | Residue |
| C | GLY318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 630 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"18406332","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VDE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Transmembrane: {"description":"Beta stranded; Name=S1","evidences":[{"source":"PubMed","id":"18406332","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VDE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 81 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18406332","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VDE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 39 |
| Details | Transmembrane: {"description":"Beta stranded; Name=S2","evidences":[{"source":"PubMed","id":"18406332","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VDE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Beta stranded; Name=S4","evidences":[{"source":"PubMed","id":"18406332","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VDE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Beta stranded; Name=S5","evidences":[{"source":"PubMed","id":"18406332","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VDE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 84 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 45 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
