2VCY
Crystal Structure of 2-Enoyl Thioester Reductase of Human FAS II
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0006879 | biological_process | intracellular iron ion homeostasis |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046513 | biological_process | ceramide biosynthetic process |
A | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0006633 | biological_process | fatty acid biosynthetic process |
B | 0006879 | biological_process | intracellular iron ion homeostasis |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046513 | biological_process | ceramide biosynthetic process |
B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A1374 |
Chain | Residue |
A | GLN256 |
A | HOH2147 |
A | HOH2148 |
A | HOH2149 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A1375 |
Chain | Residue |
A | ARG308 |
A | HOH2069 |
B | HOH2100 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A1376 |
Chain | Residue |
A | HOH2150 |
A | HOH2151 |
A | ARG139 |
A | HOH2047 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A1377 |
Chain | Residue |
A | ASN167 |
A | SER194 |
A | GLY195 |
A | LYS368 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A1378 |
Chain | Residue |
A | ALA191 |
A | SER192 |
A | ASN193 |
A | VAL215 |
A | ARG216 |
A | ARG218 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B1374 |
Chain | Residue |
A | ARG69 |
B | PRO255 |
B | GLN256 |
B | HOH2087 |
B | HOH2133 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B1375 |
Chain | Residue |
A | LYS306 |
B | ARG308 |
B | HOH2061 |
B | HOH2134 |
B | HOH2136 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B1376 |
Chain | Residue |
B | VAL103 |
B | ARG139 |
B | HOH2043 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B1377 |
Chain | Residue |
A | ALA289 |
B | ARG274 |
B | SER296 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B1378 |
Chain | Residue |
B | PRO84 |
B | ASN167 |
B | SER194 |
B | GLY195 |
B | VAL196 |
B | LYS368 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B1379 |
Chain | Residue |
B | ALA191 |
B | SER192 |
B | ASN193 |
B | SER194 |
B | VAL215 |
B | ARG216 |
B | ARG218 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8WZM3 |
Chain | Residue | Details |
A | TYR94 | |
B | TYR94 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8WZM3 |
Chain | Residue | Details |
A | ASN167 | |
B | TYR285 | |
B | PHE310 | |
B | LYS368 | |
A | ASN193 | |
A | ARG216 | |
A | TYR285 | |
A | PHE310 | |
A | LYS368 | |
B | ASN167 | |
B | ASN193 | |
B | ARG216 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DCS3 |
Chain | Residue | Details |
A | LYS61 | |
A | LYS252 | |
A | LYS267 | |
B | LYS61 | |
B | LYS252 | |
B | LYS267 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DCS3 |
Chain | Residue | Details |
A | LYS316 | |
B | LYS316 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1guf |
Chain | Residue | Details |
A | TYR94 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1guf |
Chain | Residue | Details |
B | TYR94 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1guf |
Chain | Residue | Details |
A | SER85 | |
A | ASN88 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1guf |
Chain | Residue | Details |
B | SER85 | |
B | ASN88 |