Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VAX

Crystal structure of deacetylcephalosporin C acetyltransferase (Cephalosporin C-soak)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004414	molecular_function	homoserine O-acetyltransferase activity
A	0009058	biological_process	biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009092	biological_process	homoserine metabolic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0017000	biological_process	antibiotic biosynthetic process
A	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
B	0004414	molecular_function	homoserine O-acetyltransferase activity
B	0009058	biological_process	biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009092	biological_process	homoserine metabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0017000	biological_process	antibiotic biosynthetic process
B	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
C	0004414	molecular_function	homoserine O-acetyltransferase activity
C	0009058	biological_process	biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009092	biological_process	homoserine metabolic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0017000	biological_process	antibiotic biosynthetic process
C	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
D	0004414	molecular_function	homoserine O-acetyltransferase activity
D	0009058	biological_process	biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0009092	biological_process	homoserine metabolic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0017000	biological_process	antibiotic biosynthetic process
D	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
E	0004414	molecular_function	homoserine O-acetyltransferase activity
E	0009058	biological_process	biosynthetic process
E	0009086	biological_process	methionine biosynthetic process
E	0009092	biological_process	homoserine metabolic process
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0017000	biological_process	antibiotic biosynthetic process
E	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
F	0004414	molecular_function	homoserine O-acetyltransferase activity
F	0009058	biological_process	biosynthetic process
F	0009086	biological_process	methionine biosynthetic process
F	0009092	biological_process	homoserine metabolic process
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0017000	biological_process	antibiotic biosynthetic process
F	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
G	0004414	molecular_function	homoserine O-acetyltransferase activity
G	0009058	biological_process	biosynthetic process
G	0009086	biological_process	methionine biosynthetic process
G	0009092	biological_process	homoserine metabolic process
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0017000	biological_process	antibiotic biosynthetic process
G	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
H	0004414	molecular_function	homoserine O-acetyltransferase activity
H	0009058	biological_process	biosynthetic process
H	0009086	biological_process	methionine biosynthetic process
H	0009092	biological_process	homoserine metabolic process
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0017000	biological_process	antibiotic biosynthetic process
H	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
I	0004414	molecular_function	homoserine O-acetyltransferase activity
I	0009058	biological_process	biosynthetic process
I	0009086	biological_process	methionine biosynthetic process
I	0009092	biological_process	homoserine metabolic process
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0017000	biological_process	antibiotic biosynthetic process
I	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
J	0004414	molecular_function	homoserine O-acetyltransferase activity
J	0009058	biological_process	biosynthetic process
J	0009086	biological_process	methionine biosynthetic process
J	0009092	biological_process	homoserine metabolic process
J	0016740	molecular_function	transferase activity
J	0016746	molecular_function	acyltransferase activity
J	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
J	0017000	biological_process	antibiotic biosynthetic process
J	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
K	0004414	molecular_function	homoserine O-acetyltransferase activity
K	0009058	biological_process	biosynthetic process
K	0009086	biological_process	methionine biosynthetic process
K	0009092	biological_process	homoserine metabolic process
K	0016740	molecular_function	transferase activity
K	0016746	molecular_function	acyltransferase activity
K	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
K	0017000	biological_process	antibiotic biosynthetic process
K	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
L	0004414	molecular_function	homoserine O-acetyltransferase activity
L	0009058	biological_process	biosynthetic process
L	0009086	biological_process	methionine biosynthetic process
L	0009092	biological_process	homoserine metabolic process
L	0016740	molecular_function	transferase activity
L	0016746	molecular_function	acyltransferase activity
L	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
L	0017000	biological_process	antibiotic biosynthetic process
L	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CSC A1383

Chain	Residue
A	THR58
A	ASP363
A	MET367
A	LEU59
A	THR60
A	OAS149
A	ARG218
A	TYR225
A	ARG234
A	GLN281
A	HIS362

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A1384

Chain	Residue
A	ARG124
A	VAL127
A	GLU157
A	PHE161
B	THR25
B	ILE31

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CSC B1384

Chain	Residue
B	THR58
B	LEU59
B	THR60
B	OAS149
B	ARG218
B	ASN222
B	LYS226
B	TYR277
B	GLN281
B	HIS362
B	ASP363

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B1385

Chain	Residue
A	THR25
A	ILE31
B	ARG124
B	GLU157

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CSC C1383

Chain	Residue
C	THR58
C	LEU59
C	THR60
C	OAS149
C	ARG218
C	TYR225
C	LYS226
C	TYR277
C	GLN281
C	HIS362
C	ASP363
C	MET367

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C1384

Chain	Residue
A	VAL47
C	ARG124
C	ARG128
C	GLU157

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CSC D1383

Chain	Residue
D	THR58
D	LEU59
D	THR60
D	OAS149
D	ARG218
D	TYR225
D	GLN281
D	HIS362
D	ASP363

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D1384

Chain	Residue
D	ARG124
D	ARG128
D	GLU157
D	ARG310

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CSC E1383

Chain	Residue
E	THR58
E	LEU59
E	THR60
E	OAS149
E	ARG218
E	TYR225
E	LYS226
E	ARG234
E	GLN281
E	HIS362
E	ASP363
E	MET367

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT E1384

Chain	Residue
E	GLU157
I	THR25
I	ILE31

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CSC F1384

Chain	Residue
F	THR58
F	LEU59
F	THR60
F	OAS149
F	ARG218
F	LYS226
F	ARG234
F	TYR277
F	GLN281
F	HIS362
F	PHE365
F	VAL366
F	MET367

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT F1385

Chain	Residue
F	ARG124
F	ARG128
F	GLU157
F	PHE161

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CSC G1383

Chain	Residue
G	LYS226
G	ARG234
G	GLN281
G	HIS362
G	ASP363
G	MET367
G	HOH2003
G	THR58
G	LEU59
G	THR60
G	OAS149
G	ARG218
G	TYR225

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT G1384

Chain	Residue
G	ARG128
G	GLU157

site_id	BC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CSC H1383

Chain	Residue
H	THR58
H	LEU59
H	THR60
H	TRP68
H	OAS149
H	ARG218
H	LYS226
H	ARG234
H	TYR277
H	HIS362
H	ASP363
H	PHE365
H	VAL366
H	HOH2005

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT H1384

Chain	Residue
H	ARG124
H	ARG128
H	GLU157

site_id	BC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CSC I1384

Chain	Residue
I	THR58
I	LEU59
I	THR60
I	OAS149
I	ARG218
I	ASN222
I	LYS226
I	TYR277
I	GLN281
I	HIS362
I	ASP363

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT I1385

Chain	Residue
E	THR25
I	ARG124
I	GLU157

site_id	CC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CSC J1385

Chain	Residue
J	THR58
J	LEU59
J	THR60
J	OAS149
J	ARG218
J	TYR225
J	LYS226
J	ARG234
J	TYR277
J	GLN281
J	HIS362
J	ASP363
J	PHE365
J	MET367

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CSC K1385

Chain	Residue
K	THR58
K	LEU59
K	THR60
K	OAS149
K	ARG218
K	TYR225
K	LYS226
K	TYR277
K	HIS362
K	ASP363
K	PHE365
K	VAL366

site_id	CC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CSC L1383

Chain	Residue
L	THR58
L	LEU59
L	THR60
L	OAS149
L	ARG218
L	LYS226
L	ARG234
L	TYR277
L	GLN281
L	HIS362
L	ASP363
L	PHE365
L	VAL366

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT L1384

Chain	Residue
L	ARG124
L	ARG128
L	GLU157
L	PHE161

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
A	HIS362
A	ASP333

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
J	HIS362
J	ASP333

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
K	HIS362
K	ASP333

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
L	HIS362
L	ASP333

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
B	HIS362
B	ASP333

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
C	HIS362
C	ASP333

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
D	HIS362
D	ASP333

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
E	HIS362
E	ASP333

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
F	HIS362
F	ASP333

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
G	HIS362
G	ASP333

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
H	HIS362
H	ASP333

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
I	HIS362
I	ASP333

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)